PMID: 6964387Oct 1, 1982Paper

Modulation by calcium of the potassium permeability of dog heart sarcolemmal vesicles

Proceedings of the National Academy of Sciences of the United States of America
P Caroni, E Carafoli

Abstract

The movement of K+ in heart sarcolemmal vesicles has been followed through the opposing movement of the tetraphenylphosphonium ion. Ca2+ (5-50 microM) stimulates the efflux of K+ from K+-loaded vesicles [Km(Ca2+) approximately equal to 10 microM]. and the activation requires that Ca2+ be present inside the vesicles together with K+. The efflux of 86Rb+ from K+-, Rb+-loaded vesicles is similarly stimulated by 5-50 microM Ca2+ [Km(Ca2+) approximately equal to 10 microM]. The Ca2+-induced increase of K+ permeability does not become spontaneously inactivated. The effects of some inhibitors have been tested under conditions in which Ca2+ promotes the entry of K+ into vesicles. In this system, direct interaction of the drug with the Ca2+ and K+ membrane binding site(s) was therefore studied. Tetraethylammonium ion, which inhibits the potential-dependent K+ channel, does not interfere with the effect of Ca2+ whereas quinidine (IC50 = 12 microM) and trifluoperazine (IC50 = 8 microM at 50 micrograms of sarcolemmal protein per ml) inhibit.

References

Feb 1, 1979·The Journal of General Physiology·J L Kenyon, W R Gibbons
Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J P Reeves, J L Sutko
Jan 1, 1978·Annual Review of Biophysics and Bioengineering·R W Meech
May 1, 1976·The Journal of General Physiology·R S Kass, R W Tsien
Jun 1, 1974·The Journal of General Physiology·T Begenisich, C Lynch
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P CaroniE Carafoli
Dec 1, 1958·Biochimica Et Biophysica Acta·G GARDOS

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Citations

Jul 1, 1989·Basic Research in Cardiology·D A Eyolfson, N S Dhalla
May 24, 1988·Biochimica Et Biophysica Acta·H Kuwayama
Mar 28, 1986·Biochemical and Biophysical Research Communications·H A PershadsinghJ M McDonald
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M FossetM Lazdunski
Jan 1, 1983·Annual Review of Biochemistry·L F Reichardt, R B Kelly
Mar 1, 1984·The American Journal of Physiology·R L DeHaanL J Elsas

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