PMID: 8938568Nov 1, 1996Paper

Modulation by interferons of human neutrophilic granulocyte migration

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
V AasH B Benestad

Abstract

The effect of various interferons (IFN) on neutrophilic granulocyte (PMN) random and directed migration is incompletely understood. We, therefore, investigated PMN migration with a novel micropore membrane technique. No chemotactic effect of either 10-10000 U/ml IFN-alpha or IFN-beta, or 1-1000 U/ml IFN-gamma was observed on PMN isolated from normal human venous blood. However, when present on both sides of the micropore membrane, all the IFN (1000 U/ml IFN-alpha and IFN-beta, 100 U/ml IFN-gamma) inhibited both random and directed migration toward zymosan-activated serum (ZAS). IFN-gamma was the most potent inhibitory agent and produced an inhibition of about 30%. When the bacterial peptide fMLP was used as a chemoattractant, IFN-gamma also depressed chemotaxis. Taking the reduced random migration of IFN-gamma treated cells into account, however, chemotaxis per se-toward both ZAS and fMLP-was not significantly affected. Random migration and directed migration assessed simultaneously with PMN from the same donor were clearly correlated for both control and IFN-gamma treated cells, suggesting that a general antimotility effect of IFN-gamma might explain both reduced random migration and chemotaxis. The antimotility effect of IFN-...Continue Reading

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Citations

Apr 29, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·V AasJ G Iversen
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simone P ZehntnerTrevor Owens
Jun 15, 2017·Frontiers in Cellular and Infection Microbiology·Irina MiraldaKenneth R McLeish

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