Modulation by propranolol of the lysyl cross-links in aortic elastin and collagen of the aneurysm-prone turkey

Biochemical Pharmacology
R J BoucekC F Simpson

Abstract

dl-Propranolol (propranolol) fed to immature and mature aneurysm-prone turkeys (Broad-Breasted White, BBW) for 6 weeks significantly raised the tensile strength of tissue rings from the abdominal aorta. The drug-mediated increase in tensile strength values was dose-related and independent of its heart rate- and arterial pressure-lowering effects. Propranolol acts, in part, by (a) stimulating lysyl oxidase to produce greater amounts of reactive aldehydes for intermolecular cross-links, (b) enhancing the progression of chemically unstable to stable forms of intermolecular elastin cross-links (lysinonorleucine and the desmosines), and (c) reducing the density of the age-related intermolecular cross-linking of collagen (pyridinoline). These propranolol effects on the lysyl cross-links were demonstrated in both the immature and mature animals and suggest a heretofore unrecognized potential for this widely used cardiovascular drug.

References

Apr 1, 1979·Experimental and Molecular Pathology·P J SheridanS C Benson
Mar 1, 1979·The Biochemical Journal·R J BoucekZ Gunja-Smith
Oct 1, 1978·Journal of Biochemistry·T Moriguchi, D Fujimoto
Jan 1, 1977·Advances in Experimental Medicine and Biology·W R Gray
Aug 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·A OoshimaS Udenfriend
Oct 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·S R Pinnell, G R Martin
Jan 1, 1970·Toxicology and Applied Pharmacology·C F SimpsonR F Palmer
Oct 14, 1964·Biochemical and Biophysical Research Communications·E J MillerK A Piez
Dec 21, 1965·Biochemical and Biophysical Research Communications·C FranzblauR Lampidis
Feb 21, 1967·Biochimica Et Biophysica Acta·F S Labella, S Vivian
Jan 10, 1967·Biochemical and Biophysical Research Communications·R Lent, C Franzblau
Oct 22, 1981·The New England Journal of Medicine·R J BoucekW T Butler
Oct 1, 1981·Canadian Journal of Physiology and Pharmacology·Z J Samila, S A Carter
Jan 29, 1980·Biochemical and Biophysical Research Communications·D R Eyre, H Oguchi
Aug 1, 1971·FEBS Letters·A J. Bailey, M S. Shimokomaki
Jun 25, 1957·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·M L HARKNESSD A MCDONALD
Feb 1, 1964·Experimental and Molecular Pathology·D A KIMBALLW H CARNES
May 1, 1964·Circulation Research·H WOLINSKY, S GLAGOV

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Citations

Jun 1, 1988·The Journal of Surgical Research·C BrophyM D Tilson
Jun 1, 1997·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·J J GrangeB T Baxter
Mar 21, 1998·The British Journal of Surgery·A B Wilmink, C R Quick
Nov 18, 1996·Annals of the New York Academy of Sciences·J L Cronenwett
Nov 18, 1996·Annals of the New York Academy of Sciences·M A RicciD B Pilcher
Oct 29, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Koji KurosawaDai Yamanouchi
Apr 1, 1994·Journal of Vascular Surgery·G R GadowskiM A Ricci
Oct 18, 2014·Journal of the American College of Cardiology·Judith Z GoldfingerValentin Fuster
Feb 15, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J S LindholtL Heickendorff
Jul 1, 1997·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J S LindholtH Fasting
Jun 14, 2017·Clinical Medicine Insights. Cardiology·Amit GoyalArya Mani
Feb 10, 2011·Nature Reviews. Cardiology·Ahmed KlinkZahi A Fayad
Jun 6, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Matthew A DaleB Timothy Baxter
Feb 14, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Ryoko UmebayashiJun Wada
Apr 9, 2008·Circulation·B Timothy BaxterRonald L Dalman
Nov 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·B MinkowitzV J Vigorita
Mar 23, 2021·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Duygu KocyigitBo Xu

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