Modulation of 2',5'-oligoadenylate synthetase in patients treated with alpha-interferon: effects of dose, schedule, and route of administration

Journal of Interferon Research
J A MerrittE C Borden

Abstract

The interferon (IFN)-induced intracellular enzyme 2',5'-oligoadenylate (2-5A) synthetase was measured in extracts of peripheral mononuclear cells isolated from patients receiving a 300-fold range of doses of alpha interferon (IFN-alpha). The range of enzyme induction was 2.3- to 5.7-fold. The maximum fold increase varied from individual to individual as did the dose required for maximum enzyme stimulation. The magnitude and endurance of the enzyme response was a function of IFN dose and was unrelated to the duration of treatment or number of injections or to the route of administration. The enzyme assay was a more sensitive indicator of IFN administration than was measurement of the level of circulating IFN. These results substantiate the potential of a clinical 2-5A synthetase assay for monitoring IFN treatment.

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Citations

Jun 12, 1998·Pharmacology & Therapeutics·M R Player, P F Torrence
Jan 1, 1992·Clinical Immunology and Immunopathology·E C Borden
Jan 1, 1989·Annals of the New York Academy of Sciences·D OrlicC Sandoval
Apr 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A Jones, P Selby
Aug 1, 1988·AIDS Research and Human Retroviruses·O YamadaT Kishida
Nov 23, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Snehal G ThakkarErnest C Borden
Jun 1, 1988·Journal of Interferon Research·Y S ChengE C Borden
Dec 1, 1988·Journal of Interferon Research·A M LiberatiG Peretti

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