PMID: 11933049Apr 5, 2002Paper

Modulation of 5-HT system in mice with a targeted disruption of neuromedin B receptor

Journal of Neuroscience Research
Mariko YamanoH Ohki-Hamazaki

Abstract

To assess the role of neuromedin B receptor (NMB-R) on the modulation of serotonergic (5-HT) system, the function of the 5-HT system was examined in mice lacking the NMB-R gene. Immunohistochemical analysis of brain sections revealed that 5-HT expression level in the dorsal raphe neurons was elevated in NMB-R-deficient mice compared with wild-type mice. Although restraint stress enhanced 5-HT expression in these neurons in wild-type mice, this treatment did not affect 5-HT expression level in NMB-R-deficient mice, indicating the modulation of 5-HT system in the mutant mice. Since 5-HT system is involved in responses to stress and anxiety, we characterized stress response in these mice. The number of c-Fos expressing cells in the paraventricular nucleus of the hypothalamus was higher in NMB-R-deficient mice than in wild-type mice in both basal and stressed conditions. Moreover, the plasma corticosterone level under restraint stress was elevated in NMB-R-deficient mice compared to wild-type mice. In the forced swimming tests, the duration of immobility was longer in mutant mice than in wild-type mice. These data show dysregulated response to stress in NMB-R-deficient mice. However, behavior related to anxiety, assessed by elevate...Continue Reading

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Citations

Aug 21, 2003·Progress in Neurobiology·Mark J Millan
Dec 17, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M PigeyreUNKNOWN HELENA Study group
Mar 10, 2010·The Journal of Physiology·Gabriela Silva Monteiro PaulaCarmen Cabanelas Pazos-Moura
Oct 13, 2007·Regulatory Peptides·Karen J OliveiraCarmen C Pazos-Moura
Mar 6, 2007·Behavioural Brain Research·Tania BédardZul Merali
Sep 3, 2004·Neuroscience Letters·Megan J BainBenjamin Rusak
Dec 9, 2004·The American Journal of Clinical Nutrition·Luigi BouchardLouis Pérusse

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