Modulation of a host's cell membrane nano-environment by mycobacterial glycolipids: involvement of PI(4,5)P2 signaling lipid?

Faraday Discussions
Manjari Mishra, Shobhna Kapoor


Virulence-associated glycolipids from Mycobacterium tuberculosis (Mtb) act as effector molecules during infection-in addition to proteins. Upon insertion, they alter the host cell's membrane properties modifying the host's functions to aid Mtb survival and disease course. Here we combine tether force experiments and microscopy to reveal previously unknown insights on the potential involvement of the phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) lipid in the Mtb lipid-host interaction landscape. Our data shows that Mtb lipids, having different structural and chemical make-up, distinctly alter a host's PI(4,5)P2 membrane abundance/organization and PI(4,5)P2-actin colocalization, thus impacting the plasma membrane-cytoskeletal adhesion forces. Combined with our previous findings that underscore the role of exogenous Mtb lipids in remodeling host plasma membrane organization and mechanics, this work builds upon a lipid-centric view of tubercular infections. Dynamically changing a host's plasma membrane lipid content - in response to virulent lipids - might represent a so far unexplored mechanism invoked by Mtb to modulate the host cell's adhesive properties to escape immune surveillance. These findings will deepen our collectiv...Continue Reading


Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B J SpargoJ H Crowe
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·P V EscribáJ A García-Sevilla
Mar 15, 1996·Science·P De CamilliP Novick
May 4, 2002·Annual Review of Biophysics and Biomolecular Structure·Stuart McLaughlinDiana Murray
May 15, 2002·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Thomas R PowersRaymond E Goldstein
May 23, 2002·Biophysical Journal·Robert M Hochmuth, Warren D Marcus
Jun 13, 2002·Physical Review Letters·Imre DerényiJacques Prost
Apr 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Rutilio A FrattiVojo Deretic
Nov 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jeanne KwikMichael Edidin
Dec 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Katharina GausWendy Jessup
Dec 24, 2004·Journal of Cell Science·Vera DesMaraisJohn Condeelis
Sep 27, 2005·Biophysical Journal·Mingzhai SunMichel Grandbois
Apr 4, 2006·Nature Reviews. Microbiology·Richard D HaywardKenneth G Campellone
May 13, 2006·Annual Review of Biophysics and Biomolecular Structure·Michael P SheetzHans-Günther Döbereiner
Jan 3, 2007·Nature Cell Biology·Ken JacobsonRichard G W Anderson
Jun 7, 2007·Journal of Cell Science·Mingzhai SunGabor Forgacs
Jan 2, 2010·Science·Daniel Lingwood, Kai Simons
Jul 19, 2011·Nature Reviews. Microbiology·Hyeilin HamKim Orth
Dec 2, 2011·Current Opinion in Cell Biology·Timothy A Springer, Michael L Dustin
Nov 6, 2012·Trends in Cell Biology·Alba Diz-MuñozOrion D Weiner
Nov 20, 2012·Frontiers in Physiology·Zhongkui HongGabor Forgacs
Apr 9, 2013·Journal of the American Chemical Society·Shobhna KapoorRoland Winter
Jul 12, 2013·PloS One·Bruno PontesH Moysés Nussenzveig
Aug 12, 2014·Cold Spring Harbor Perspectives in Medicine·Mary Jackson
Sep 11, 2014·Scientific Reports·Luca ChiericoGiuseppe Battaglia
Sep 18, 2014·Journal of the American Chemical Society·Helgi I IngólfssonSiewert J Marrink
Feb 24, 2016·Chemistry and Physics of Lipids·G Aditya KumarAmitabha Chattopadhyay
Jun 24, 2016·The Journal of Biological Chemistry·Ren ShengWonhwa Cho
Mar 13, 2018·Chemistry and Physics of Lipids·Gopinath ViswanathanAmitabha Chattopadhyay
Sep 8, 2019·Scientific Reports·Manjari MishraShobhna Kapoor

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