Modulation of ACD6 dependent hyperimmunity by natural alleles of an Arabidopsis thaliana NLR resistance gene

PLoS Genetics
Wangsheng ZhuDetlef Weigel

Abstract

Plants defend themselves against pathogens by activating an array of immune responses. Unfortunately, immunity programs may also cause unintended collateral damage to the plant itself. The quantitative disease resistance gene ACCELERATED CELL DEATH 6 (ACD6) serves to balance growth and pathogen resistance in natural populations of Arabidopsis thaliana. An autoimmune allele, ACD6-Est, which strongly reduces growth under specific laboratory conditions, is found in over 10% of wild strains. There is, however, extensive variation in the strength of the autoimmune phenotype expressed by strains with an ACD6-Est allele, indicative of genetic modifiers. Quantitative genetic analysis suggests that ACD6 activity can be modulated in diverse ways, with different strains often carrying different large-effect modifiers. One modifier is SUPPRESSOR OF NPR1-1, CONSTITUTIVE 1 (SNC1), located in a highly polymorphic cluster of nucleotide-binding domain and leucine-rich repeat (NLR) immune receptor genes, which are prototypes for qualitative disease resistance genes. Allelic variation at SNC1 correlates with ACD6-Est activity in multiple accessions, and a common structural variant affecting the NL linker sequence can explain differences in SNC1 a...Continue Reading

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Citations

Oct 17, 2019·Cold Spring Harbor Perspectives in Biology·Eugenia PitsiliNuria S Coll
Dec 22, 2019·International Journal of Molecular Sciences·Kamila PluhařováTetiana Kalachova
Sep 25, 2020·The New Phytologist·Wei-Lin WanEunyoung Chae
May 28, 2019·Plant Science : an International Journal of Experimental Plant Biology·Matthew J MarcecKiwamu Tanaka

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Datasets Mentioned

BETA
AY510018

Methods Mentioned

BETA
transgenic
PCR
genotyping

Software Mentioned

R
exonerate
MassLynx
MEGA6
TargetLynx
qtl package

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