Modulation of acute and chronic inflammatory processes by a traditional medicine preparation GCSB-5 both in vitro and in vivo animal models

Journal of Ethnopharmacology
Hwa-Jin ChungSang Kook Lee

Abstract

GCSB-5 is a traditional medicine preparation composed with six oriental herbs which have been widely used for the inflammatory diseases in Asia. In the present study, we have demonstrated the anti-inflammatory effects of GCSB-5 in vivo and in vitro along with its underlying mechanism of action. The acute and chronic inflammation models in animals were applied to investigate the anti-inflammatory effects of GCSB-5. To further investigate the mechanism of the anti-inflammatory activity, lipopolysaccharide (LPS)-induced murine macrophage RAW264.7 cells were also employed. In in vivo animal model, oral administration of GCSB-5 significantly inhibited TPA- and carrageenan-induced acute edema and adjuvant-induced arthritis. The vascular permeability, leukocyte migration, and granuloma formation were also inhibited by GCSB-5. In accordance, GCSB-5 suppressed the LPS-induced nitric oxide (NO) production by the downregulation of mRNA and protein expressions of inducible nitric oxide synthase (iNOS). GCSB-5 also suppressed the expressions of cyclooxygenase-2 (COX-2) and inflammatory cytokines such as interleukin-1beta and interferon-beta. The activation of NF-kappaB by LPS was also alleviated by GCSB-5, which correlated with its inhibito...Continue Reading

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Citations

Aug 25, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Saba Zuhair HusseinYasmin Anum Mohd Yusof
Apr 5, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Joon-Ki KimSun-Mee Lee
May 17, 2011·Journal of Ethnopharmacology·Tae-Hoon KimSun-Mee Lee
Sep 24, 2013·Pain·Joon-Shik ShinMyeong Soo Lee
May 24, 2016·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Joon-Shik ShinIn-Hyuk Ha
Aug 19, 2016·BMC Complementary and Alternative Medicine·Yoon Jae LeeIn-Hyuk Ha
Mar 30, 2017·Journal of Basic and Clinical Physiology and Pharmacology·Oluwafemi Gabriel OluwoleSolomon Umukoro
Jun 27, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Yesol JungManho Kim
Sep 20, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Hee Seung ChoiIn-Hyuk Ha
Nov 29, 2017·BioMed Research International·HaiXing GouXinGang Lu
Aug 5, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Jinho LeeIn-Hyuk Ha

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