Modulation of acute diarrheal illness by persistent bacterial infection.

Infection and Immunity
Megan E McBeeDavid B Schauer

Abstract

Acute diarrheal illness is a global health problem that may be exacerbated by concurrent infection. Using Citrobacter rodentium, a murine model of attaching and effacing diarrheagenic Escherichia coli, we demonstrate that persistent Helicobacter hepaticus infection modulates host responses to diarrheal disease, resulting in delayed recovery from weight loss and from tissue damage. Chronic colitis in concurrently infected mice is characterized by macrophage and Foxp3(+) regulatory T-cell accumulation. Prolonged disease is also associated with increased interleukin-17 expression, which may be due to suppression of gamma interferon during the acute phase of diarrheal infection. This new model of polymicrobial infection provides insight into the mechanism by which subclinical infection can exacerbate morbidity due to an unrelated self-limiting infection.

References

May 4, 2001·Microbes and Infection·S A Luperchio, D B Schauer
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cameron P SimmonsThomas T MacDonald
Aug 21, 2002·The Journal of Experimental Medicine·Marika C KullbergAlan Sher
Apr 2, 2003·Nature Reviews. Immunology·Allan McI Mowat
May 23, 2003·Infection and Immunity·Bruce A VallanceB Brett Finlay
Apr 23, 2004·Infection and Immunity·Vincent B YoungDavid B Schauer
Feb 8, 2005·Journal of Clinical Microbiology·Trung Vu NguyenAndrej Weintraub
Mar 9, 2005·Immunology Letters·Kevin J MaloyFiona Powrie
Mar 24, 2005·Nature Immunology·Yasmine Belkaid, Barry T Rouse
Nov 18, 2005·Trends in Immunology·Brent S McKenzieDaniel J Cua
Nov 29, 2005·Cellular Microbiology·Rosanna MundySiouxsie Wiles
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chien-Chang ChenHai Ning Shi
Mar 15, 2006·Laboratory Investigation; a Journal of Technical Methods and Pathology·Arlin B RogersJames G Fox
May 4, 2006·The Journal of Clinical Investigation·David YenDonna Rennick
Aug 24, 2006·Infection and Immunity·Siouxsie WilesGad Frankel
Oct 13, 2006·The Journal of Experimental Medicine·Marika C KullbergAlan Sher
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Holm H UhligFiona Powrie
Jan 20, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Xinchun ChenEmmanuel Katsanis
Feb 6, 2007·The Journal of Biological Chemistry·Xuexian O YangChen Dong
May 2, 2007·Infection and Immunity·Diana BorenshteinDavid B Schauer
Nov 29, 2007·Current Opinion in Gastroenterology·Diana BorenshteinDavid B Schauer
Dec 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jan Hendrik NiessJörg Reimann
Feb 29, 2008·Annual Review of Immunology·Natalya V SerbinaEric G Pamer
Jul 25, 2008·Nature·Ruslan Medzhitov

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Citations

Oct 9, 2012·The Journal of Clinical Investigation·Emily M MallickDavid B Schauer
Aug 29, 2009·Helicobacter·Mario M D'Elios, Leif P Andersen
Nov 26, 2010·Cell Biochemistry and Function·Sara M Hoffman, Sherry D Fleming
Mar 14, 2009·European Journal of Immunology·Andrea M Cooper

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