Modulation of acute visceral nociception and bladder inflammation by plant triterpene, alpha, beta-amyrin in a mouse model of cystitis: role of tachykinin NK(1)-receptors, and K(+)(ATP) channels

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
R C P Lima-JúniorFlávia A Santos

Abstract

We previously described the visceral antinociceptive property of alpha, beta-amyrin in a mouse model of cystitis induced by cyclophosphamide (CPM). This study examined the contribution of vanilloid-1 (TRPV1), peripheral NK1 receptors to CPM-evoked nociceptive behaviors and bladder edema, and its possible modulation by alpha, beta-amyrin. The effect of alpha, beta-amyrin (10, 30, and 100 mg/kg, p. o.) and N-acetylcysteine (NAC) on CPM (400 mg/kg, i. p.)-induced cystitis was studied in mice. Sensory deafferentation was done by a high dose capsaicin. The parameters analysed were: CPM-evoked noxious behaviors, bladder edema, vascular permeability, and NK(1) immunoreactivity. To assess the role of K(+) (ATP) channels in alpha, beta-amyrin effect, animals were pretreated with glibenclamide. alpha, beta-amyrin (30 and 100 mg/kg) and NAC significantly (p < 0.01) suppressed the visceral pain-related behaviors and NK(1) immunoreactivity, but bladder edema was reduced weakly. Glibenclamide reversed the effects of alpha, beta-amyrin. Sensory deafferentation by capsaicin significantly reduced the nociceptive responses and the NK(1) immunoreactivity to noxious stimulation by CPM. alpha, beta-amyrin attenuates CPM-induced visceral pain and bl...Continue Reading

Citations

Mar 15, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Caroline M MeloFlávia A Santos
Jul 27, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Vinícios T BoeiraFernanda B Morrone
Jul 6, 2014·Biological & Pharmaceutical Bulletin·Se Jin ParkJong Hoon Ryu
Sep 8, 2010·World Journal of Gastroenterology : WJG·Caroline-Mourão MeloMariana-Helena Chaves
Jan 1, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S A Holanda PintoV S Rao
Aug 2, 2016·Chinese Medicine·Hui-Hui XiaoMan-Sau Wong

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