Modulation of adipocyte size and fat pad weight via resveratrol releasing scaffolds implanted into the epididymal adipose tissue.

Journal of Biomedical Materials Research. Part a
Kendall P MurphyR Michael Gower

Abstract

Lipid overload of the adipose tissue, which can be caused by overnutrition, underlies metabolic disease. We hypothesized that increasing the energy demand of adipose tissue is a promising strategy to combat excessive lipid accumulation. Resveratrol, a natural polyphenol, activates lipid catabolism in fat tissue; however, its clinical success is hindered by poor bioavailability. Here, we implanted resveratrol releasing poly(lactide-co-glycolide) scaffolds into epididymal fat to overcome its poor bioavailability with the goal of enhancing local lipid catabolism. In lean mice, resveratrol scaffolds decreased adipocyte size relative to scaffolds with no drug, a response that correlated with AMP kinase activation. Immunohistochemistry indicated that macrophages and multinucleated giant cells within the scaffold expressed carnitine palmitoyltransferase 1 (CPT1) at higher levels than other cells in the adipose tissue. Furthermore, resveratrol increased CPT1 levels in cultured macrophages. Taken together, we propose that resveratrol scaffolds decrease adipocyte size because resveratrol increases lipid utilization in scaffold-infiltrating immune cells, possibly through elevating CPT1 levels or activity. In a follow-up study, mice that r...Continue Reading

References

Feb 23, 2007·Annual Review of Nutrition·Robin E DuncanHei Sook Sul
Oct 2, 2007·British Journal of Pharmacology·C E QuinnG E McVeigh
Mar 8, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Elena RigamontiBart Staels
Apr 11, 2008·Nature Reviews. Molecular Cell Biology·Adilson GuilhermeMichael P Czech
Jun 6, 2009·American Journal of Physiology. Endocrinology and Metabolism·Katja S C GollischLaurie J Goodyear
Aug 22, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M SchreursF R van der Leij
Dec 23, 2009·The International Journal of Biochemistry & Cell Biology·Maryam AhmadianHei Sook Sul
May 29, 2010·Circulation Research·Ajay Chawla
Aug 18, 2010·Disease Models & Mechanisms·Julio E AyalaUNKNOWN NIH Mouse Metabolic Phenotyping Center Consortium
Dec 1, 2010·Cancer Chemotherapy and Pharmacology·Izet M KapetanovicDavid L McCormick
May 6, 2011·The Journal of Nutritional Biochemistry·Arrate LasaMaría del Puy Portillo
May 17, 2011·Nutrition & Metabolism·Goiuri AlberdiMaría P Portillo
Nov 8, 2011·Cell Metabolism·Dominique Langin
Nov 30, 2011·Methods in Molecular Biology·Chao-Yung Wang, James K Liao
Jul 1, 2010·Nutrients·Mohsen Meydani, Syeda T Hasan
Sep 5, 2012·Molecular Nutrition & Food Research·Arrate LasaMaría P Portillo
Jan 15, 2013·Journal of Physiology and Biochemistry·Saioa Gomez-ZoritaChristian Carpéné
Feb 5, 2013·Lipids in Health and Disease·Koji NagaoTeruyoshi Yanagita
Feb 16, 2013·The American Journal of Medicine·Jessica L UnickUNKNOWN Look AHEAD Research Group
Apr 19, 2013·Journal of Biomedical Materials Research. Part a·Shiow-Yunn SheuTuoh Wu
Jun 25, 2013·Tissue Engineering. Part a·Ann-Christina BradyCherie L Stabler
Dec 10, 2013·The Journal of Nutritional Biochemistry·Shu WangChwan-Li Shen
Jun 10, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K A HlavatyL D Shea
Oct 28, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·James M Smoliga, Otis Blanchard
Oct 29, 2014·American Journal of Disaster Medicine·Seth K KatzKimberly B Gill
Nov 6, 2014·PloS One·Teresa Oviedo SocarrásSilvia P Andrade
Nov 19, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Leixuri AguirreMaria P Portillo
Feb 26, 2015·American Journal of Physiology. Endocrinology and Metabolism·Maria Ida MalandrinoLaura Herrero
Jul 8, 2015·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Melanie McGrice, Kathlene Don Paul
Dec 24, 2015·The Journal of Experimental Medicine·Luke A J O'Neill, Edward J Pearce
May 6, 2016·Frontiers in Endocrinology·Sung Sik ChoeJae Bum Kim
May 14, 2016·Journal of Nanomedicine & Nanotechnology·Katy E RutledgeEhsan Jabbarzadeh
Jul 12, 2016·Nature Reviews. Immunology·Luke A J O'NeillJeff Rathmell
Sep 11, 2016·Biochimica Et Biophysica Acta·Dmitry Namgaladze, Bernhard Brüne
Dec 10, 2016·The Journal of Endocrinology·Liping Luo, Meilian Liu

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Citations

May 25, 2021·Critical Reviews in Food Science and Nutrition·José João Caires Serina, Paula Cristina Machado Ferreira Castilho

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