Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle

Free Radical Biology & Medicine
Emanuele MarzettiChristiaan Leeuwenburgh

Abstract

Aging is inevitably associated with a progressive loss of muscle mass and strength, a condition also known as sarcopenia of aging. Although the precise mechanisms underlying this syndrome have not been completely elucidated, recent studies point toward several key cellular mechanisms that could contribute to age-associated muscle loss. Among these, mitochondrial dysfunction and deregulation of apoptotic signaling have emerged as critical players in the onset and progression of sarcopenia. Interestingly, calorie restriction, a well-known antiaging intervention, and, more recently, exercise training have been shown to beneficially affect both mitochondrial function and apoptotic signaling in skeletal muscle from young and old animals. Preliminary observations also indicate that even a small (8%) reduction in food intake may still provide protective effects against sarcopenia and cellular remodeling in aging skeletal muscle, with the advantage of being more applicable to human subjects than the traditional 30-40% restriction regimen. The most recent evidence on the relevance of skeletal muscle apoptosis to sarcopenia, as well as its modulation by calorie restriction and exercise, is reviewed.

References

Nov 1, 1992·Clinical Physiology·T J OverendM S Lefcoe
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·G A CortopassiN Arnheim
Mar 15, 1992·Mechanisms of Ageing and Development·M BrownJ O Holloszy
Nov 1, 1984·Mechanisms of Ageing and Development·T SatoK Kato
Oct 15, 1984·Mechanisms of Ageing and Development·R H FittsJ O Holloszy
Nov 1, 1995·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·J Lexell
Nov 1, 1995·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·G D Cartee
Nov 1, 1995·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·B M Carlson
May 1, 1996·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·G D CarteeR P Farrar
Jan 1, 1997·Journal of the American Geriatrics Society·L P Fried, J M Guralnik
Feb 1, 1997·Aging : Clinical and Experimental Research·R J McCarterC A McMahan
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·E R Barton-DavisH L Sweeney
Jan 15, 1999·Neuropathology and Applied Neurobiology·M Podhorska-OkolowU Carraro
Feb 13, 1999·The Journal of Biological Chemistry·X M SunG M Cohen
Feb 18, 1999·JAMA : the Journal of the American Medical Association·T RantanenL White
Mar 17, 1999·Biochimica Et Biophysica Acta·G A Cortopassi, A Wong
Sep 17, 1999·Muscle & Nerve·D L AllenV R Edgerton
Feb 7, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J WanagatJ M Aiken
Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·S B LalM E Harper
Oct 30, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·M Pollack, C Leeuwenburgh
Dec 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·M RenatusG S Salvesen
Dec 12, 2001·Journal of the American College of Cardiology·H RuettenS Dimmeler
Dec 26, 2001·Pharmacology & Therapeutics·K C ZimmermannD R Green
Jan 17, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Amie Dirks, Christiaan Leeuwenburgh
Feb 15, 2002·Rheumatology International·Sule ArslanErsin Tan
May 17, 2002·Journal of Applied Physiology·Entela A BuaJudd M Aiken
Jun 4, 2002·The Journal of Biological Chemistry·Min ChenRoberta A Gottlieb
Jun 18, 2002·American Journal of Physiology. Endocrinology and Metabolism·R SreekumarK Sreekumaran Nair
Aug 21, 2002·American Journal of Respiratory and Critical Care Medicine·Michael I Lewis
Sep 21, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·E Jeffrey MetterRobin Conwit
Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·B DrewC Leeuwenburgh
Mar 11, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rebecca StarkieBente Klarlund Pedersen
Oct 17, 2003·The Journal of Biological Chemistry·Rammohan V RaoDale E Bredesen
Nov 25, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Christiaan Leeuwenburgh
Jan 1, 2004·The Journal of Clinical Investigation·Jie DuWilliam E Mitch
Jan 7, 2004·Medicine and Science in Sports and Exercise·Kyle M TarpenningSteven A Hawkins
Jan 22, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Susan H McKiernanJudd Aiken
Jan 23, 2004·American Journal of Physiology. Endocrinology and Metabolism·Lisa BevilacquaMary-Ellen Harper
Apr 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Luigi FontanaJohn O Holloszy
May 11, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Parco M SiuStephen E Alway
Jan 15, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christiaan LeeuwenburghEsther E Dupont-Versteegden
Mar 19, 2005·The Journal of Physiology·Parco M Siu, Stephen E Alway
Jun 14, 2005·Pflügers Archiv : European journal of physiology·Samantha A WhitmanMichael P Godard

❮ Previous
Next ❯

Citations

Nov 15, 2008·Apoptosis : an International Journal on Programmed Cell Death·Hongjie DuanJing Lin
Jun 12, 2012·Biogerontology·Darren G CandowPhilip D Chilibeck
Jul 21, 2012·Endocrine·Jonathan P Gumucio, Christopher L Mendias
Aug 1, 2009·The Journal of Biological Chemistry·Denny L CottleChristina A Mitchell
May 5, 2011·Antioxidants & Redox Signaling·John M Lawler, Allyson Hindle
Jan 5, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Julianna H HuangDavid A Hood
Jun 4, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Christy S CarterDrake Morgan
Aug 14, 2012·Journal of Aging Research·Courtney M PetersonEric Ravussin
Oct 14, 2010·Journal of Cell Science·Arnold Y SeoChristiaan Leeuwenburgh
Nov 4, 2009·International Journal of Molecular Medicine·Valeria RighiA Aria Tzika
Jun 16, 2012·International Journal of Biological Sciences·Susan Tsivitse Arthur, Ian D Cooley
Jan 31, 2012·Journal of Nutrition and Metabolism·Marianne F BairdGordon F Bickerstaff
Aug 29, 2013·Journal of Diabetes Research·Saeid Golbidi, Ismail Laher
Sep 15, 2012·Investigational New Drugs·Durvanei Augusto MariaAna Marisa Chudzinski-Tavassi
Jun 8, 2013·Free Radical Biology & Medicine·Michael E WalshHolly Van Remmen
Jun 25, 2016·The Journal of Surgical Research·Hongjie DuanYonghui Yu
Jul 1, 2009·Biochimica Et Biophysica Acta·Hrvoje Augustin, Linda Partridge
May 20, 2009·Biochimica Et Biophysica Acta·Emanuele MarzettiChristiaan Leeuwenburgh
Aug 12, 2008·Ageing Research Reviews·Hae Young ChungChristiaan Leeuwenburgh
Jun 27, 2008·Mechanisms of Ageing and Development·Emanuele MarzettiChristiaan Leeuwenburgh
Oct 10, 2008·Aging Cell·Arnold Y SeoChristiaan Leeuwenburgh
Mar 26, 2009·BioFactors·Emanuele MarzettiChristiaan Leeuwenburgh
Apr 6, 2012·Journal of Cachexia, Sarcopenia and Muscle·Kunihiro Sakuma, Akihiko Yamaguchi
Aug 8, 2015·Ageing Research Reviews·Anabela La CollaAndrea Vasconsuelo
Apr 12, 2016·Ageing Research Reviews·Kersti TeppTuuli Kaambre
Oct 9, 2014·Pflügers Archiv : European journal of physiology·Carla MenesesClaudio Cabello-Verrugio
Apr 12, 2015·Ageing Research Reviews·John Tower
Nov 9, 2011·Progress in Neurobiology·Fabio Sambataro, Maria Pennuto
Jun 12, 2012·Oxidative Medicine and Cellular Longevity·Enrico DoriaFulvio Marzatico
Jul 30, 2014·Frontiers in Aging Neuroscience·Fabian Sanchis-GomarAlejandro Lucia
Jul 2, 2014·Frontiers in Psychiatry·Andrea Camaz Deslandes
Feb 13, 2016·Cell Death and Differentiation·C ScioratiP Rovere-Querini
Nov 25, 2017·General Thoracic and Cardiovascular Surgery·Kay Maeda, Yoshikatsu Saiki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Caspases in Metabolic Diseases

Caspases, the family of cysteine proteases are involved in programmed cell death, but their role in metabolic diseases, inflammation and immunity has been of interested. Discover the latest research on caspases in metabolic diseases here.