Modulation of age-related changes in immune functions of protein-deficient senescence-accelerated mice by dietary nucleoside-nucleotide mixture supplementation

The British Journal of Nutrition
C K AmehoS Yamamoto

Abstract

In the present study we examined the immune-enhancing effect of a nucleoside-nucleotide mixture on the non-specific T-cell immune functions of senescence-accelerated mice (SAM) fed on a low-protein diet. The immune functions studied were in vitro thymic and splenic cell lymphoproliferative responses to phytohaemagglutinin, lipopolysaccharide and concanavalin A and their production of interleukin-2 (IL-2) and interferon-gamma (INF-gamma) in response to mitogen stimulation. SAMP8 mice aged 3 and 6 months were used. In each age group, mice were fed on diets containing either 50 g casein/kg, 50 g casein/kg supplemented with 5 g nucleoside-nucleotide mixture/kg or 200 g casein/kg for 3 weeks. The supplemented 3- and 6-month-old mice had higher (P < 0.05) thymic and splenic cell counts compared with the low-protein group. In both age groups of mice, concanavalin A induced higher (P < 0.05) total thymic and splenic lymphoproliferative responses for the nucleoside-nucleotide mixture-supplemented group compared with the 50 g casein/kg dietary groups. Thymic and splenic production of IL-2 was higher for the 3-month-old mice in both the supplemented and the 200 g casein/kg dietary groups. INF-gamma production in the supplemented 3-month-o...Continue Reading

References

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Citations

Oct 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Soheil Zorofchian MoghadamtousiKeivan Zandi
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·F B Rudolph, C T Van Buren
May 23, 2008·Journal of Clinical Immunology·Haydeé González-MartínezMaría Cristina González-Torres
Aug 2, 2011·Asian Pacific Journal of Tropical Medicine·Omeje Edwin OgechukwuPeter Proksch
Oct 26, 2005·Neurobiology of Aging·Damien ColasNicole Sarda

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