Modulation of antibiotic resistance in bacterial pathogens by oleanolic acid and ursolic acid

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Anna KurekKrystyna I Wolska

Abstract

Antibiotic resistance among bacterial pathogens is a serious problem for human and veterinary medicine, which necessitates the development of novel therapeutics and antimicrobial strategies. Some plant-derived compounds, e.g. pentacyclic triterpenoids such as oleanolic acid (OA) and ursolic acid (UA), have potential as a new class of antibacterial agents as they are active against many bacterial species, both Gram-positive and Gram-negative, and specifically target the cell envelope. The aim of the present study was to investigate the influence of OA and UA on the susceptibility of four bacterial pathogens (Pseudomonas aeruginosa, Listeria monocytogenes, Staphylococcus aureus and Staphylococcus epidermidis) to the β-lactam antibiotics ampicillin (Ap) and oxacillin (Ox). Antimicrobial assays were conducted with bacteria growing in liquid suspension cultures (planktonic cells) or as biofilms. Using FICI value estimation and the time-kill method it was demonstrated that in some combinations, the tested compounds acted in synergy to lower the susceptibility of S. aureus, S. epidermidis and L. monocytogenes to ampicillin and oxacillin, but no synergy was observed for P. aeruginosa. These results indicate that OA and UA may be useful...Continue Reading

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Citations

Jan 24, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Patrícia G G do NascimentoJosé Galberto M Costa
Jan 29, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chao-Min WangChang-Hung Chou
Nov 28, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Łukasz WoźniakKrystian Marszałek
Jan 20, 2016·Journal of Pharmaceutical and Biomedical Analysis·Bart BlanchaertAnn Van Schepdael
Apr 13, 2015·Food Chemistry·Karim ChouaïbM'hamed Ali Hamza
Jan 27, 2015·European Journal of Medicinal Chemistry·Haijun ChenJia Zhou
Sep 2, 2016·Chemistry & Biodiversity·Guo-Qiang LiYao-Lan Li
Jun 9, 2017·Journal of Basic Microbiology·Sandra F Oloketuyi, Fazlurrahman Khan
Jul 12, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chao-Min WangChang-Hung Chou
Mar 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wenzhi WangQingguo Meng
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Feb 20, 2019·AMB Express·Niranjana Sri SundaramoorthySaisubramanian Nagarajan
May 21, 2020·Current Drug Targets·Aditi SharmaVikas Jaitak

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