Modulation of antioxidant enzymes in bleomycin-treated rats by vitamin C and beta-carotene

Nutrition and Cancer
V G DesaiR J Feuers

Abstract

Bleomycin (BLM), an antineoplastic drug, is known to induce DNA strand breaks and is also mutagenic in mammalian cells; however, its mechanism of action is not well understood. It has been proposed that BLM cytotoxicity is mediated through the generation of reactive oxygen species. We have determined the effects of BLM on endogenous hepatic antioxidant enzymes such as glutathione peroxidase (GPx), glutathione reductase, and glucose-6-phosphate dehydrogenase in rats exposed to BLM in conjunction with dietary vitamins, vitamin C and beta-carotene (BC). Male Fischer 344 rats of two different age groups were treated with BLM in the presence or absence of antioxidant vitamins. In control animals, an age-associated decrease in GPx activity was noted (p < 0.05). The decrease in GPx activity observed in BLM-treated old animals given vitamin C was significant (p < 0.05) compared with BLM-treated young animals fed vitamin C. BC moderately induced GPx and glutathione reductase activities in old BLM-treated animals; however, the increase in GPx was statistically significant (p < 0.05) only compared with old controls. A similar increase was noted in the activities of all the enzymes examined in young animals. Our results indicate that BLM e...Continue Reading

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Citations

Jan 22, 2002·Journal of Ethnopharmacology·S K S SaradaW Selvamurthy
Nov 15, 2007·Antioxidants & Redox Signaling·Brian J Day
Feb 29, 2016·Pharmacological Reports : PR·Mehmet GürbüzelIlyas Capoglu
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Mar 9, 2002·Toxicology and Applied Pharmacology·Michael GleiBeatrice Louise Pool-Zobel

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