Modulation of anxiety-related behaviors by mu- and kappa-opioid receptor agonists depends on the social status of mice

Peptides
Natalia N KudryavtsevaJan M Van Ree

Abstract

This study was aimed to determine the effects of mu- and kappa-opioid receptor activation in relation to the social status of mice, being a winner with repeated experience of victories or a loser with repeated experience of social defeats. The behaviors of the animals were assessed in a social encounter test measuring the communicative behavior towards a familiar and an unfamiliar partner behind a perforated transparent partition (partition test) and in an elevated plus-maze test estimating the anxiety level of mice. Placebo and graded doses of the mu-opioid receptor agonist DAMGO (0.5 and 2 mg/kg s.c.) and the kappa-opioid receptor agonist U-50,488H (0.6, 1.25, and 2.5 mg/kg s.c.) were administered to the control mice, winners and losers in two experiments. In the partition test, the winners spent somewhat more time and the losers less time than the controls in the vicinity of their partner probably related to a lower and higher level of anxiety respectively. In the plus-maze test the losers appeared to have a somewhat higher anxiety level than the controls and winners. In both tests DAMGO produced anxiogenic-like effects in the winners and the controls, but not in the losers. Winners hardly responded to treatment with U-50,48...Continue Reading

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Citations

Sep 19, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Walter WittmannChristoph Schwarzer
Nov 21, 2008·Behavioural Pharmacology·Stephen R HodgsonShoshana Eitan
Oct 26, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Natalia N KudryavtsevaNatalia P Bondar
Jun 2, 2009·Pharmacology & Therapeutics·Christoph Schwarzer
Apr 21, 2009·Neuropharmacology·José M TrigoRafael Maldonado
Oct 29, 2008·Behavioural Brain Research·Sam G BuckmanShoshana Eitan
Feb 19, 2008·Psychoneuroendocrinology·Andras Bilkei-GorzoAndreas Zimmer
Mar 22, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·G GerraC Donnini
Jun 20, 2012·British Journal of Pharmacology·Maria C OlianasPierluigi Onali
Apr 29, 2005·Brain Research. Molecular Brain Research·Andrey V GoloshchapovJan M Van Ree
Mar 10, 2006·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Natalia KudryavtsevaJan M Van Ree
May 20, 2015·Acta Pharmacologica Sinica·Ai HangJing-gen Liu
Dec 3, 2014·Frontiers in Pharmacology·Catherine M CahillChristopher J Evans
Mar 2, 2018·Frontiers in Pharmacology·Abigail Laman-MahargBrian C Trainor
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Aug 15, 2020·Frontiers in Neuroscience·Kelly F PatonBronwyn M Kivell
Nov 22, 2016·Journal of Neuroscience Research·Abigail Laman-Maharg, Brian C Trainor
Sep 12, 2020·The Journal of Pharmacology and Experimental Therapeutics·Kelly F PatonBronwyn M Kivell
Jun 8, 2018·Progress in Neuro-psychopharmacology & Biological Psychiatry·Alexia V WilliamsBrian C Trainor
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Arvin Haj-MirzaianAhmad Reza Dehpour
Jul 1, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rajan NikbakhshAhmad Reza Dehpour

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