Modulation of apoptosis and viral latency - an axis to be well understood for successful cure of human immunodeficiency virus

The Journal of General Virology
Uddhav Timilsina, Ritu Gaur

Abstract

Human immunodeficiency virus (HIV) is the causative agent of the deadly disease AIDS, which is characterized by the progressive decline of CD4(+)T-cells. HIV-1-encoded proteins such as envelope gp120 (glycoprotein gp120), Tat (trans-activator of transcription), Nef (negative regulatory factor), Vpr (viral protein R), Vpu (viral protein unique) and protease are known to be effective in modulating host cell signalling pathways that lead to an alteration in apoptosis of both HIV-infected and uninfected bystander cells. Depending on the stage of the virus life cycle and host cell type, these viral proteins act as mediators of pro- or anti-apoptotic signals. HIV latency in viral reservoirs is a persistent phenomenon that has remained beyond the control of the human immune system. To cure HIV infections completely, it is crucial to reactivate latent HIV from cellular pools and to drive these apoptosis-resistant cells towards death. Several previous studies have reported the role of HIV-encoded proteins in apoptosis modulation, but the molecular basis for apoptosis evasion of some chronically HIV-infected cells and reactivated latently HIV-infected cells still needs to be elucidated. The current review summarizes our present understan...Continue Reading

References

Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·V KolesnitchenkoD I Cohen
Jul 30, 2002·The EMBO Journal·Maria CastedoGuido Kroemer
Oct 9, 2002·The Journal of Biological Chemistry·Raquel BlancoIván Ventoso
Sep 23, 2003·Immunity·David G BrooksJerome A Zack
Mar 3, 2004·The Journal of Experimental Medicine·Jean-Luc PerfettiniGuido Kroemer
Mar 23, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Constantinos PetrovasPeter D Katsikis
Jul 31, 2004·The Journal of Biological Chemistry·Samuel A WilliamsWarner C Greene
Feb 5, 2005·Retrovirology·Jean de MareuilErwann P Loret
Sep 22, 2005·Nature Reviews. Microbiology·Sébastien NisoleAli Saïb
Apr 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jean-Philippe HerbeuvalGene M Shearer
Sep 20, 2006·Cancer Research·Morgane Le BrasCatherine Brenner
Jan 24, 2007·The Journal of Biological Chemistry·Reem BerroFatah Kashanchi
Jan 8, 2008·Trends in Immunology·Georges Herbein, Kashif Aziz Khan
Jan 29, 2008·Current Pharmaceutical Design·J E McLeanZ F Zakeri
Feb 23, 2008·The Journal of Clinical Investigation·Laura A NapolitanoJoseph M McCune
Jun 3, 2008·Experimental and Molecular Pathology·Joshua L AndersenVicente Planelles
Jun 3, 2008·PLoS Pathogens·Lorenzo GalluzziGuido Kroemer
Aug 2, 2008·Microbes and Infection·Masako NomaguchiAkio Adachi
Sep 27, 2008·The Open Virology Journal·Zilin NieAndrew D Badley
Oct 14, 2008·Blood·Alberto Bosque, Vicente Planelles
May 23, 2009·Renal Failure·Himanshu VashisthaPravin C Singhal
Jun 3, 2009·Retrovirology·Christopher M Coleman, Li Wu
Jun 23, 2009·Nature Medicine·Nicolas ChomontRafick-Pierre Sékaly
Aug 8, 2009·Clinical and Experimental Immunology·K S PeggsJ P Allison
Oct 17, 2009·Retrovirology·Bhawna PooniaMaria S Salvato

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Citations

May 22, 2018·Biotechnology & Genetic Engineering Reviews·Guido van MarleM John Gill
Oct 5, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Iratxe Del Río-IñiguezAndrés Alcover
Feb 23, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Lucia PastorDenise Naniche
May 28, 2019·Cellular and Molecular Life Sciences : CMLS·Ivan Sadowski, Farhad B Hashemi
Sep 17, 2020·Southern African Journal of HIV Medicine·Alexander M L Hayes
Mar 16, 2021·Molecular Therapy. Nucleic Acids·Saikat Boliar, David G Russell
Jul 4, 2020·Biochemical Pharmacology·Clémentine WalletChristian Schwartz

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis