Modulation of arterial pressure by P2 purinoceptors in the paraventricular nucleus of the hypothalamus of awake rats

Autonomic Neuroscience : Basic & Clinical
Josiane C CruzB H Machado

Abstract

In the present study we evaluated the role of purinergic mechanisms in the PVN on the tonic modulation of the autonomic function to the cardiovascular system as well on the cardiovascular responses to peripheral chemoreflex activation in awake rats. Guide-cannulae were bilaterally implanted in the direction of the PVN of male Wistar rats. Femoral artery and vein were catheterized one day before the experiments. Chemoreflex was activated with KCN (80 μg/0.05 ml, i.v.) before and after microinjections of P2 receptors antagonist into the PVN. Microinjection of PPADS, a non selective P2X antagonist, into the PVN (n=6) produced a significant increase in the baseline MAP (99±2 vs 112±3 mmHg) and HR (332±8 vs 375±8 bpm) but had no effect on the pressor and bradycardic responses to chemoreflex activation. Intravenous injection of vasopressin receptors antagonist after microinjection of PPADS into the PVN produced no effect on the increased baseline MAP. Simultaneous microinjection of PPADS and KYN into the PVN (n=6) had no effect in the baseline MAP, HR or in the pressor and bradycardic responses to chemoreflex activation. We conclude that P2 purinoceptors in the PVN are involved in the modulation of baseline autonomic function to the ...Continue Reading

References

Jan 1, 1993·Journal of the Autonomic Nervous System·K G Franchini, E M Krieger
Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Y F LiK P Patel
Jul 23, 2002·Autonomic Neuroscience : Basic & Clinical·Renata C H BarrosBenedito H Machado
Mar 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eiji Shigetomi, Fusao Kato
Jan 12, 2005·Physiology & Behavior·Luciano G FernandesBenedito H Machado
May 28, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Maram K ReddyHarold D Schultz
Jul 5, 2005·Nature Neuroscience·Grant R J GordonJaideep S Bains
Aug 1, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Yi-Fan LiKaushik P Patel
Jan 10, 2009·Autonomic Neuroscience : Basic & Clinical·Josiane C Cruz, Benedito H Machado
Apr 18, 2009·Respiratory Physiology & Neurobiology·Erica M Granjeiro, Benedito H Machado
Sep 29, 2009·Autonomic Neuroscience : Basic & Clinical·Josiane de Campos CruzBenedito H Machado

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Citations

Dec 18, 2013·Pharmacological Reviews·Geoffrey Burnstock, Vera Ralevic
Apr 24, 2015·Journal of Neurophysiology·Hildebrando Candido Ferreira-NetoJavier E Stern

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