Modulation of axonal excitability mediated by surround electric activity: an intra-axonal study

Experimental Brain Research
J D KocsisK L Cummins

Abstract

Intra-axonal recordings were obtained in vitro from frog sciatic nerve axons. Adjusting whole nerve stimulation current to just subthreshold for the impaled axon elicited triphasic threshold changes in that axon. Threshold changes were determined by direct intra-axonal current application. Graded subthreshold depolarizations were present in many axons during the passage of action potentials in surrounding axons. When nerve branches were stimulated and axon recordings were obtained from the main nerve trunk, both branches, the one that activated the impaled axon and the one that did not, elicited threshold changes in the impaled axon. These data indicate on a cellular level that impulse activity in an intact nerve bundle can modulate the excitability of adjacent nonactivated fibers.

Citations

Aug 1, 1993·Journal of Neurocytology·K FriedM Devor
Oct 26, 1992·Neuroscience Letters·D UtzschneiderM Devor
Oct 3, 2002·Behavioural Brain Research·R G HallinG Wu
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Mar 23, 2004·Nature Reviews. Neuroscience·Dominique Debanne
Apr 30, 2011·Physiological Reviews·Dominique DebanneGisèle Alcaraz
May 22, 2019·The European Journal of Neuroscience·Francesco Bolzoni, Elzbieta Jankowska
Oct 13, 2020·Physiological Measurement·James HopeAndrew McDaid

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