Modulation of B1 and B2 kinin receptors expression levels in the hippocampus of rats after audiogenic kindling and with limbic recruitment, a model of temporal lobe epilepsy

International Immunopharmacology
Marilia G Alves Goulart PereiraClaudio Miguel Costa-Neto

Abstract

Epileptic seizures are hypersynchronous, paroxystic and abnormal neuronal discharges. Epilepsies are characterized by diverse mechanisms involving alteration of excitatory and inhibitory neurotransmission that result in hyperexcitability of the central nervous system (CNS). Enhanced neuronal excitability can also be achieved by inflammatory processes, including the participation of cytokines, prostaglandins or kinins, molecules known to be involved in either triggering or in the establishment of inflammation. Multiple inductions of audiogenic seizures in the Wistar audiogenic rat (WAR) strain are a model of temporal lobe epilepsy (TLE), due to the recruitment of limbic areas such as hippocampus and amygdala. In this study we investigated the modulation of the B1 and B2 kinin receptors expression levels in neonatal WARs as well as in adult WARs subjected to the TLE model. The expression levels of pro-inflammatory (IL-1 beta) and anti-inflammatory (IL-10) cytokines were also evaluated, as well as cyclooxygenase (COX-2). Our results showed that the B1 and B2 kinin receptors mRNAs were up-regulated about 7- and 4-fold, respectively, in the hippocampus of kindled WARs. On the other hand, the expressions of the IL-1 beta, IL-10 and C...Continue Reading

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Citations

Jun 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Atheir I AbbasBryan L Roth
Aug 6, 2015·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Isis C NascimentoHenning Ulrich
May 5, 2012·Neurochemistry International·Ibeth Guevara-Lora
Jan 24, 2009·Experimental Neurology·K RijkersJ S Vles
Feb 25, 2014·Clinical Science·Claudio M Costa-NetoLucas T Parreiras-E-Silva
Jan 10, 2008·International Immunopharmacology·Claudio M Costa-NetoPedro P C Souza
Feb 17, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·N Garcia-Cairasco
May 17, 2017·Epilepsy & Behavior : E&B·Norberto Garcia-CairascoJosé A Cortes de Oliveira

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