Modulation of Bacterial Multidrug Resistance Efflux Pumps of the Major Facilitator Superfamily

International Journal of Bacteriology
Sanath KumarManuel F Varela

Abstract

Bacterial infections pose a serious public health concern, especially when an infectious disease has a multidrug resistant causative agent. Such multidrug resistant bacteria can compromise the clinical utility of major chemotherapeutic antimicrobial agents. Drug and multidrug resistant bacteria harbor several distinct molecular mechanisms for resistance. Bacterial antimicrobial agent efflux pumps represent a major mechanism of clinical resistance. The major facilitator superfamily (MFS) is one of the largest groups of solute transporters to date and includes a significant number of bacterial drug and multidrug efflux pumps. We review recent work on the modulation of multidrug efflux pumps, paying special attention to those transporters belonging primarily to the MFS.

References

Nov 15, 1977·Biochimica Et Biophysica Acta·M Bentaboulet, A Kepes
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·O Lomovskaya, K Lewis
Aug 1, 1992·Current Opinion in Cell Biology·J K GriffithP J Henderson
Apr 1, 1992·Antimicrobial Agents and Chemotherapy·S B Levy
Aug 21, 1992·Science·H C Neu
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A A NeyfakhL B Chen
Jan 30, 1990·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·P J Henderson, M C Maiden
Sep 1, 1989·Antimicrobial Agents and Chemotherapy·K UbukataM Konno
Feb 12, 1987·Nature·M C MaidenP J Henderson
Mar 29, 1994·Biochimica Et Biophysica Acta·R Krämer
Jan 1, 1994·Annual Review of Microbiology·W Hillen, C Berens
Sep 30, 1994·Journal of Medicinal Chemistry·T C BardenV J Lee
Aug 1, 1994·Current Opinion in Cell Biology·P C Maloney
Nov 1, 1993·Biochemical Society Transactions·P J HendersonJ K Griffith
Mar 1, 1994·Trends in Biochemical Sciences·K Lewis
Aug 1, 1993·Current Opinion in Cell Biology·P J Henderson
Aug 1, 1993·The Journal of Infectious Diseases·S P CohenS B Levy
Nov 2, 1993·Biochimica Et Biophysica Acta·B Poolman, W N Konings
Jan 1, 1993·Antimicrobial Agents and Chemotherapy·A A NeyfakhG W Kaatz
Jan 1, 1993·Trends in Biochemical Sciences·M D Marger, M H Saier
Aug 7, 1996·Biochimica Et Biophysica Acta·M F Varela, T H Wilson
Nov 1, 1996·Antimicrobial Agents and Chemotherapy·P N Markham, A A Neyfakh
Dec 1, 1996·Microbiological Reviews·I T PaulsenR A Skurray
Feb 1, 1997·Journal of Bacteriology·R Ohki, M Murata
Apr 1, 1997·Journal of Bacteriology·D G ThanassiH Nikaido
Oct 23, 1997·Antimicrobial Agents and Chemotherapy·A Tait-KamradtJ Sutcliffe
Mar 6, 1998·Scientific American·S B Levy
Apr 8, 1998·Microbiology and Molecular Biology Reviews : MMBR·S S PaoM H Saier
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·P C HsiehK Lewis

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Citations

Nov 27, 2019·International Journal of Molecular Sciences·Giannamaria Annunziato
Dec 19, 2019·Molecular Biology and Evolution·Jeff MaltasKevin B Wood
Jan 24, 2020·Journal of Medical Microbiology·Chris R ProctorNigel G Ternan
Sep 9, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Devendra H DusanePaul Stoodley
Aug 1, 2015·The Journal of General and Applied Microbiology·Marta SochockaJanusz Boratyński
Dec 18, 2015·Future Microbiology·Sylvie Buffet-BataillonAnne Jolivet-Gougeon
Oct 25, 2017·The Journal of Membrane Biology·Carmine J SlipskiDenice C Bay
Jul 5, 2018·Frontiers in Molecular Biosciences·Karim Housseini B IssaIsabelle Broutin
Jan 31, 2015·International Journal of Environmental Research and Public Health·Jody L AndersenManuel F Varela
Nov 11, 2016·Archives of Microbiology·Prathusha KakarlaManuel F Varela
Dec 3, 2016·Frontiers in Microbiology·Tikam Chand DakalVinod Yadav
Jan 8, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Yi SunXiaodong Xia
Jun 16, 2015·Frontiers in Microbiology·Martyn F SymmonsVassiliy N Bavro
May 26, 2020·BMC Microbiology·Magna Coroa LimaMaria Aparecida Scatamburlo Moreira
May 10, 2017·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Jeongjin Kim, Juhee Ahn
Dec 20, 2020·Antibiotics·Stephen P TeoSimon Gibbons
Feb 19, 2021·Frontiers in Microbiology·Bansi RanpariyaSougata Ghosh
Apr 24, 2021·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Gabriela Christina KuhlJuliano De Dea Lindner
Jul 17, 2021·Current Microbiology·Ana Carolina Justino de AraújoHenrique Douglas Melo Coutinho
Aug 8, 2021·International Journal of Molecular Sciences·Ana G AbrilTomás G Villa
Aug 22, 2021·Folia Microbiologica·Priscilla Ramos FreitasHenrique Douglas Melo Coutinho

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Methods Mentioned

BETA
phosphotransferase

Software Mentioned

BLAST

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