PMID: 40255May 1, 1979

Modulation of benzodiazepine binding site sensitivity

Pharmacology, Biochemistry, and Behavior
J F Tallman, D W Gallager

Abstract

Recent studies on agents which alter benzodiazepine binding site sensitivity in brain are described. GABAergic agonists enhance and antagonists inhibit binding to the brain specific benzodiazepine binding site, and the binding can be correlated with effects on neuronal cell firing in the dorsal raphe nucleus. Anions such as chloride, iodide and nitrite also enhance (3H)diazepam binding and this enhancement is consistent with their role in postsynaptic inhibition. Pretreatment of animals with the anticonvulsant, diphenylhydantoin, enhances both diazepam binding and the electrophysiological response to diazepam suggesting one possible locus for the anticonvulsant action of diphenylhydantoin in brain. Taken together, these results suggest the existence of a GABA/Cl- ionophore/BZ binding complex in brain. Preliminary results on the purification of the BZ component of this complex and fluorescent probes for its study are described.

References

Apr 1, 1976·The Journal of Pharmacy and Pharmacology·A Dray, D W Straughan
Oct 20, 1977·Nature·C BraestrupR F Squires
Jul 27, 1978·Nature·J F TallmanD W Gallager
Sep 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·W E Haefely
Mar 5, 1979·Life Sciences·J F TallmanD W Gallager
Sep 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·C Braestrup, R F Squires
Sep 1, 1977·Nature·S N Kozhechkin, R U Ostrovskay
Oct 10, 1970·Nature·K Krnjević
Jul 14, 1966·Annals of the New York Academy of Sciences·J C Eccles

Citations

Aug 11, 1981·Molecular and Cellular Biochemistry·R L Macdonald, A B Young
Oct 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·L TurskiK H Sontag
Oct 26, 1979·European Journal of Pharmacology·R C SpethH I Yamamura
Oct 17, 1980·European Journal of Pharmacology·P SkolnickK Irmscher
Mar 22, 1988·European Journal of Pharmacology·L G MillerR I Shader
Jun 1, 1981·Pharmacology, Biochemistry, and Behavior·L G DavisD Reker
Jan 1, 1982·Pharmacology, Biochemistry, and Behavior·C C SmithJ F Tallman
Jul 1, 1981·Brain Research·C R Walker, J H Peacock
Nov 1, 1984·Pharmacology, Biochemistry, and Behavior·R C DruganS F Maier
May 5, 1980·Brain Research·D W GallagerJ F Tallman
Dec 14, 1979·Biochemical and Biophysical Research Communications·G TunnicliffT T Ngo
Jan 1, 1981·Medicinal Research Reviews·P Skolnick, S M Paul

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