Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5.

Heart Failure Reviews
David HoStephen F Vatner

Abstract

Despite remarkable advances in therapy, heart failure remains a leading cause of morbidity and mortality. Although enhanced beta-adrenergic receptor stimulation is part of normal physiologic adaptation to either the increase in physiologic demand or decrease in cardiac function, chronic beta-adrenergic stimulation has been associated with increased mortality and morbidity in both animal models and humans. For example, overexpression of cardiac Gsalpha or beta-adrenergic receptors in transgenic mice results in enhanced cardiac function in young animals, but with prolonged overstimulation of this pathway, cardiomyopathy develops in these mice as they age. Similarly, chronic sympathomimetic amine therapy increases morbidity and mortality in patients with heart failure. Conversely, the use of beta-blockade has proven to be of benefit and is currently part of the standard of care for heart failure. It is conceivable that interrupting distal mechanisms in the beta-adrenergic receptor-G protein-adenylyl cyclase pathway may also provide targets for future therapeutic modalities for heart failure. Interestingly, there are two major isoforms of adenylyl cyclase (AC) in the heart (type 5 and type 6), which may exert opposite effects on th...Continue Reading

References

Jan 1, 1979·Annual Review of Biochemistry·E G Krebs, J A Beavo
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·C Londos, J Wolff
May 1, 1977·British Heart Journal·J D StonerD C Harrison
Apr 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·R W AlexanderR J Lefkowitz
Feb 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D B Bylund
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M Yoshimura, D M Cooper
Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R T PremontR Iyengar
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S KatsushikaY Ishikawa
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P G FeinsteinR R Reed
Aug 1, 1991·The American Journal of Cardiology·H ItohA Sakuma
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·B N Gao, A G Gilman
Aug 1, 1990·Circulation·M R Bristow
Dec 1, 1989·The Journal of Clinical Investigation·D E VatnerC J Homcy
Aug 14, 1987·The American Journal of Cardiology·E M GilbertJ W Mason
Aug 14, 1987·The American Journal of Cardiology·G ZipperleF Heinrich
Apr 1, 1972·The Journal of Clinical Investigation·S F VatnerE Braunwald
Sep 19, 1974·The New England Journal of Medicine·N H GuihaC J Limas
Feb 10, 1967·Annals of the New York Academy of Sciences·R P Ahlquist
Jul 1, 1984·British Heart Journal·M C PetchR M Goodfellow
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·S T HolgateK F Austen
Jul 22, 1982·The New England Journal of Medicine·M R BristowE B Stinson
Sep 25, 1995·Biochemical and Biophysical Research Communications·J M PatersonF A Antoni
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·W J KochR J Lefkowitz

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Citations

Dec 17, 2010·Basic Research in Cardiology·Wito RichterMarco Conti
Oct 24, 2012·Nature Reviews. Cardiology·Changwon KhoRoger J Hajjar
Aug 31, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jean C HardwickJeffrey L Ardell
Nov 28, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·Jörg H BräunigRoland Seifert
Mar 14, 2014·Pflügers Archiv : European journal of physiology·Anthony J Baker
Apr 30, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Stephen F VatnerDorothy E Vatner
Jan 20, 2012·Heart Failure Reviews·Bodh I Jugdutt
Jun 19, 2015·Neurology·Niccolo E MencacciKailash P Bhatia
Jun 17, 2015·Oxidative Medicine and Cellular Longevity·Weihua ZhangRui Wang
Apr 12, 2016·Maturitas·Gaetano Santulli, Guido Iaccarino
Jan 26, 2018·Anesthesia and Analgesia·Michael J JackaPhilip J Devereaux
Apr 16, 2016·F1000Research·Surinder Kumar, David B Lombard
Aug 14, 2019·Heart Failure Reviews·Daniel Chikere AliLi Changxing
Jun 19, 2013·Pharmacological Reviews·Utako YokoyamaYoshihiro Ishikawa
Sep 6, 2013·The Journal of Pharmacology and Experimental Therapeutics·Cameron S BrandCarmen W Dessauer
Jan 27, 2016·PloS One·Marcus R StreitStefan E Hardt
Apr 24, 2015·Aging Cell·Valter D LongoLuigi Fontana
Aug 28, 2018·Frontiers in Pharmacology·Claudio de LuciaWalter J Koch
Sep 21, 2019·Movement Disorders Clinical Practice·Nirosen VijiaratnamAlberto J Espay
Jan 1, 2020·Cells·Marion DelaunayDario Diviani
Oct 23, 2020·Ageing Research Reviews·Stephen F VatnerDorothy E Vatner

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