Modulation of Ca2+ oscillation and melatonin secretion by BKCa channel activity in rat pinealocytes

American Journal of Physiology. Cell Physiology
Hiroya MizutaniYuji Imaizumi

Abstract

The pineal glands regulate circadian rhythm through the synthesis and secretion of melatonin. The stimulation of nicotinic acetylcholine receptor due to parasympathetic nerve activity causes an increase in intracellular Ca(2+) concentration and eventually downregulates melatonin production. Our previous report shows that rat pinealocytes have spontaneous and nicotine-induced Ca(2+) oscillations that are evoked by membrane depolarization followed by Ca(2+) influx through voltage-dependent Ca(2+) channels (VDCCs). These Ca(2+) oscillations are supposed to contribute to the inhibitory mechanism of melatonin secretion. Here we examined the involvement of large-conductance Ca(2+)-activated K(+) (BKCa) channel conductance on the regulation of Ca(2+) oscillation and melatonin production in rat pinealocytes. Spontaneous Ca(2+) oscillations were markedly enhanced by BKCa channel blockers (1 μM paxilline or 100 nM iberiotoxin). Nicotine (100 μM)-induced Ca(2+) oscillations were also augmented by paxilline. In contrast, spontaneous Ca(2+) oscillations were abolished by BKCa channel opener [3 μM 12,14-dichlorodehydroabietic acid (diCl-DHAA)]. Under whole cell voltage-clamp configurations, depolarization-elicited outward currents were signi...Continue Reading

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Citations

Apr 6, 2018·Frontiers in Physiology·Xiaozhen YangYongxu Cheng
May 26, 2017·Invertebrate Neuroscience : in·Leonor Mendoza-VargasHéctor Solís-Chagoyán
Sep 23, 2020·Proceedings of the National Academy of Sciences of the United States of America·Longgang NiuZhao-Wen Wang

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