Modulation of cardiac hypertrophy by estrogens

Advances in Experimental Medicine and Biology
T PelzerL Neyses

Abstract

Gender-specific differences in heart disease have long been known but it has only been since the advent of molecular biology that it has become possible to investigate the molecular mechanisms. Most biochemical work in the last 50 years has focused on the characterization of the steroid hormones involved in gender specificity. More recently, the cloning of the steroid receptors and characterization of the signaling pathways through these proteins has given new insights into the mechanisms underlying the mode of action of steroid hormones. It has also become clear that the steroid receptors can be classified into families (receptors for thyroid hormone, glucocorticoids, estrogens, androgens, retinoic acid, and so called orphan receptors of mostly unknown function). The structures of these receptors show very close resemblance and all are DNA-binding proteins acting as transcription factors. Some (if not all) act as repressors of transcription of some genes in the native state and are converted to activators (or perhaps repressors of other genes) upon binding of the cognate hormone. Naturally, classical target tissues for estrogens and androgens have been studied first and only in very recent years has it been recognized that est...Continue Reading

Citations

Sep 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·M JankowskiJ Gutkowska
Mar 22, 2002·Nature·Hong-Bo XinSidney Fleischer
Jun 26, 2003·Clinical and Experimental Pharmacology & Physiology·Claire L CurlGeorge Kotsanas
Jun 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·C J FriddleJ Bristow
Feb 5, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Leanne GrobanMark C Chappell
Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·P H McNultyT Caulin-Glaser
Aug 14, 1999·Progress in Biophysics and Molecular Biology·Y Shimoni

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