PMID: 9416736Jan 7, 1998Paper

Modulation of cardiac sodium current by alpha1-stimulation and volatile anesthetics

Anesthesiology
H U WeigtZ J Bosnjak

Abstract

Alpha1-adrenoceptor stimulation is known to produce electrophysiologic changes in cardiac tissues, which may involve modulations of the fast inward Na+ current (I(Na)). A direct prodysrhythmic alpha1-mediated interaction between catecholamines and halothane has been demonstrated, supporting the hypothesis that generation of halothane-epinephrine dysrhythmias may involve slowed conduction, leading to reentry. In this study, we examined the effects of a selective alpha1-adrenergic receptor agonist, methoxamine, on cardiac I(Na) in the absence and presence of equianesthetic concentrations of halothane and isoflurane in single ventricular myocytes from adult guinea pig hearts. I(Na) was recorded using the standard whole-cell configuration of the patch-clamp technique. Voltage clamp protocols initiated from two different holding potentials (V(H)) were applied to examine state-dependent effects of methoxamine in the presence of anesthetics. Steady state activation and inactivation and recovery from inactivation were characterized using standard protocols. Methoxamine decreased I(Na) in a concentration- and voltage-dependent manner, being more potent at the depolarized V(H). Halothane and isoflurane interacted synergistically with met...Continue Reading

References

Nov 1, 1977·The Journal of General Physiology·F Bezanilla, C M Armstrong
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Feb 1, 1997·Anesthesia and Analgesia·H U WeigtZ J Bosnjak

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Citations

Feb 12, 2004·Journal of Molecular and Cellular Cardiology·Lucas J HerfstHabo J Jongsma
Aug 14, 1999·Progress in Biophysics and Molecular Biology·Y Shimoni
Feb 15, 2000·Journal of Cardiovascular Pharmacology·M L Martínez, C Delgado
Mar 10, 2015·Journal of Molecular and Cellular Cardiology·Céline Marionneau, Hugues Abriel
Jan 24, 2006·Clinics in Plastic Surgery·Joseph P Hunstad, Marguerite E Aitken
Jul 3, 2004·Journal of Cardiothoracic and Vascular Anesthesia·Mark W CrawfordRobert Gow

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