Modulation of CASC2/miR-21/PTEN pathway sensitizes cervical cancer to cisplatin

Archives of Biochemistry and Biophysics
Yeqian FengLili Sun

Abstract

Cisplatin (DDP) -based chemotherapy is a standard strategy for cervical cancer, while chemoresistance remains a challenge. Recent evidence highlights the crucial regulatory roles of long non-coding RNAs (lncRNA) in tumor biology. However, the roles and regulatory mechanisms of the novel lncRNA, cancer susceptibility candidate 2 (CASC2), in cervical cancer tumorigenesis and chemoresistance are poorly understood. In this study, CASC2 expression was down-regulated in cervical cancer tissues, and was related to a shorter survival time and poorer clinicopathologic features. Exogenous CACS2 alone was sufficient to inhibit cervical cancer cell proliferation and amplified DDP-induced repression of cell proliferation. A lower expression of CACS2 was observed in the DDP-resistant cervical cancer tissues, compared to DDP-sensitive cancer tissues; CACS2 overexpression could sensitize DDP-resistant cervical cancer cell (HeLa/DDP and CaSki/DDP) to DDP. Further functional experiments indicate that CASC2 upregulated PTEN expression by direct inhibiting miR-21 in the DDP-resistant cancer cells, leading to the down-regulation of p-AKT protein. In DDP-resistant cervical cancer tissues, miR-21 was up-regulated while PTEN was down-regulated. Taken ...Continue Reading

References


❮ Previous
Next ❯

Citations

Mar 8, 2018·Acta Biochimica Et Biophysica Sinica·Zhiqiong WangYifei Wu
Apr 18, 2019·Journal of Experimental & Clinical Cancer Research : CR·Zhuoran ZhangYongping You
May 8, 2020·Immunotherapy·Dmitrii ShekGolo Ahlenstiel
Dec 25, 2019·Cold Spring Harbor Perspectives in Medicine·Erin SellarsLeonardo Salmena
Sep 16, 2018·Journal of Experimental & Clinical Cancer Research : CR·Wang LiLin Huang
Aug 24, 2018·Journal of Hematology & Oncology·Hui SunMi-Die Xu
Jul 10, 2020·World Journal of Surgical Oncology·Yiming ZhuTao Zhu
Jan 11, 2021·Experimental and Molecular Pathology·Mohammad TaheriMarcel E Dinger
Nov 10, 2020·Current Opinion in Pharmacology·Dominik DiefenbachThomas Efferth
Mar 9, 2020·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Wenxiao JiangXueqiong Zhu
Sep 25, 2020·Asia-Pacific Journal of Clinical Oncology·Rana Muhammad UsmanFaiz Anwer
Sep 28, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jia Chen, Gaojun Li
Jun 9, 2021·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Amir Sadra Zangouei, Meysam Moghbeli
Aug 3, 2021·The Kaohsiung Journal of Medical Sciences·Zhi-Hui WuMin Liu
Aug 29, 2021·Molecular and Cellular Biochemistry·Tandrima Mitra, Selvakumar Elangovan
May 15, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jing GuoJianhong Zhou
Dec 17, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Fang GuoYu-Mei Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.