Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits

PloS One
Yasuhiro IchikawaDavid M Roth

Abstract

Anthracyclines are chemotherapeutic drugs known to induce heart failure in a dose-dependent manner. Mechanisms involved in anthracycline cardiotoxicity are an area of relevant investigation. Caveolins bind, organize and regulate receptors and signaling molecules within cell membranes. Caveolin-3 (Cav-3), integrins and related membrane repair proteins can function as cardioprotective proteins. Expression of these proteins in anthracycline-induced heart failure has not been evaluated. We tested the hypothesis that daunorubicin alters cardioprotective protein expression in the heart. Rabbits were administered daunorubicin (3 mg/kg, IV) weekly, for three weeks or nine weeks. Nine weeks but not three weeks of daunorubicin resulted in progressive reduced left ventricular function. Cav-3 expression in the heart was unchanged at three weeks of daunorubicin and increased in nine week treated rabbits when compared to control hearts. Electron microscopy showed caveolae in the heart were increased and mitochondrial number and size were decreased after nine weeks of daunorubicin. Activated beta-1 (β1) integrin and the membrane repair protein MG53 were increased after nine weeks of daunorubicin vs. controls with no change at the three week t...Continue Reading

References

Jan 22, 1998·The American Journal of Physiology·N OkaY Ishikawa
Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·C G PhamR S Ross
Dec 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·A PiechJ-L Balligand
Jan 24, 2003·Human & Experimental Toxicology·Ivona KlimtováMichaela Adamcová
Apr 8, 2003·Anti-cancer Drugs·Martin M BélangerJacques Couet
Oct 5, 2007·Annual Review of Pharmacology and Toxicology·Hemal H PatelPaul A Insel
Nov 6, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Daniela VolonteFerruccio Galbiati
Jun 3, 2010·Circulation·Chun-Mei CaoRui-Ping Xiao
Jul 28, 2010·Archives of Internal Medicine·Helena J van der PalLeontien C Kremer
Feb 3, 2011·Journal of Molecular and Cellular Cardiology·Martin StěrbaVladimír Geršl
Feb 3, 2011·Cardiovascular Research·Yan ZhangRui-Ping Xiao
Feb 8, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Jean-François JasminMichael P Lisanti
May 28, 2011·Journal of the American College of Cardiology·Yousuke T HorikawaDavid M Roth
Jul 13, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasuhiro IchikawaYoshihiro Ishikawa
Aug 4, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Heidi N FridolfssonHemal H Patel
Oct 30, 2012·Nature Medicine·Sui ZhangEdward T H Yeh
Dec 12, 2012·Journal of Proteome Research·Jae-Sung YiYoung-Gyu Ko
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Aug 30, 2014·Journal of the American College of Cardiology·Pimprapa Vejpongsa, Edward T H Yeh
Nov 5, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sharon Israeli-RosenbergRobert S Ross
Nov 20, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ye ZhangYunpeng Liu
Nov 26, 2014·Circulation. Heart Failure·Maryline MoulinRenée Ventura-Clapier
Aug 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elizabeth A M FeijenEric J Chow
Nov 4, 2015·Physiology·Alisa D BlazekNoah Weisleder
Mar 19, 2016·Circulation Research·Carrie G Lenneman, Douglas B Sawyer
Mar 31, 2016·Basic Research in Cardiology·Jan M SchillingDavid M Roth
Jul 4, 2016·Medical Oncology·Ibrahim Fanous, Patrick Dillon
Oct 22, 2016·American Journal of Physiology. Cell Physiology·Adam KassanHemal H Patel
Oct 13, 2016·The New England Journal of Medicine·Javid J Moslehi

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Citations

Jan 22, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·So Yeon KimHemal H Patel
Apr 10, 2020·Advanced Healthcare Materials·Cheavar A Blair, Beth L Pruitt
Jun 6, 2020·Annual Review of Biomedical Engineering·Erica A CastilloBeth L Pruitt
Mar 30, 2021·Research in Veterinary Science·Mitsuhiro IsakaRyuji Araki
May 29, 2021·Clinical Science·Anna NarezkinaAlice E Zemljic-Harpf

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Methods Mentioned

BETA
Assay
electron microscopy

Software Mentioned

image

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