Modulation of cell death pathways to apoptosis and necrosis of H2O2-treated rat thymocytes by lipocortin I

Biochemical and Biophysical Research Communications
T SakamotoF Hirata

Abstract

Lipocortin I, also called annexin I, a calcium and phospholipid binding protein, protected rat thymocytes from H2O2-elicited necrosis and facilitated H2O2-induced apoptosis, while anti-lipocortin I antibody enhanced H202-elicited necrosis by blocking H202-induced apoptosis. Essentially similar results were obtained with phospholipase A2 inhibitors and activators such as 3,4-octyadecyl-benzylacrylic acid and melittin, respectively. Available evidence suggests that lipocortin I modulates signals for cell death pathways of H2O2-treated rat thymocytes to apoptosis and necrosis by regulating cellular phospholipase A2 activities but not by inhibiting membrane lipid peroxidation.

Citations

Aug 19, 2006·Cell Death and Differentiation·T LiuK G Wiman
Apr 9, 2004·BMC Cancer·Jamboor K VishwanathaVelliyur K Gopalakrishnan
Mar 31, 1998·Environmental Health Perspectives·L T FrameJ E Leakey
May 15, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Julia PolandPranav Sinha
Mar 1, 1997·Expert Opinion on Investigational Drugs·U Tibes, W G Friebe
Dec 3, 2014·Pharmacology & Therapeutics·Chengxue QinRebecca H Ritchie
Dec 11, 2007·Biochemical Pharmacology·Sam Maher, Siobhán McClean
Aug 5, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Lei ZhangZhi-yuan Zhang
Jul 18, 2006·Biochimica Et Biophysica Acta·Raushan T Kurmasheva, Peter J Houghton
Apr 12, 2005·European Journal of Cell Biology·Mariana Roesch ElyFranz X Bosch
Oct 6, 2012·Biochemical and Biophysical Research Communications·Qing-Yi LuJianyu Rao
Jul 31, 2013·Environmental Toxicology and Pharmacology·Goran Gajski, Vera Garaj-Vrhovac
May 25, 2004·The Journal of Biological Chemistry·Eva C VaqueroAnna S Gukovskaya
Apr 21, 1997·FEBS Letters·B C Kim, J H Kim
Mar 14, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Qing-Yi LuJian Yu Rao
Dec 8, 2007·Cell Biochemistry and Function·L I NadolnikS V Lupachyk
Sep 9, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Ying CaoConstance T Albarracin
Jan 12, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lina H K Lim, Shazib Pervaiz
Mar 8, 2007·Acta Biochimica Et Biophysica Sinica·Jinbo HanChengwu Chi
Aug 11, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kim L WangConstance T Albarracin
Sep 11, 1999·Toxicon : Official Journal of the International Society on Toxinology·S S SainiJ W Peterson
Mar 21, 1998·Pharmacology & Therapeutics·M Raffray, G M Cohen
May 14, 2003·Cellular Signalling·Sajal Chakraborti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis