Modulation of cholinergic functions by serotonin and possible implications in memory: general data and focus on 5-HT(1A) receptors of the medial septum

Behavioural Brain Research
Hélène Jeltsch-DavidJean-Christophe Cassel

Abstract

Cholinergic systems were linked to cognitive processes like attention and memory. Other neurotransmitter systems having minor influence on cognitive functions - as shown by the weakness of the effects of their selective lesions - modulate cholinergic functions. The serotonergic system is such a system. Conjoined functional changes in cholinergic and serotonergic systems may have marked cognitive consequences [Cassel JC, Jeltsch H. Serotoninergic modulation of cholinergic function in the central nervous system: cognitive implications. Neuroscience 1995;69(1):1-41; Steckler T, Sahgal A. The role of serotoninergic-cholinergic interactions in the mediation of cognitive behaviour. Behav Brain Res 1995;67:165-99]. A crucial issue in that concern is the identification of the neuroanatomical and neuropharmacological substrates where functional effects of serotonergic/cholinergic interactions originate. Approaches relying on lesions and intracerebral cell grafting, on systemic drug-cocktail injections, or even on intracerebral drug infusions represent the main avenues on which our knowledge about the role of serotonergic/cholinergic interactions has progressed. The present review will visit some of these avenues and discuss their contri...Continue Reading

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Citations

Nov 26, 2010·Psychopharmacology·Gregory V Carr, Irwin Lucki
May 12, 2010·Experimental Brain Research·Sangu MuthurajuGovindasamy Ilavazhagan
Aug 31, 2013·Experimental Brain Research·María Esther Olvera-CortésMiguel Angel López-Vázquez
Apr 20, 2014·European Journal of Pharmacology·Miguel Ángel López-VázquezMaría Esther Olvera-Cortés
Jul 21, 2012·Neurochemical Research·Saida HaiderDarakhshan J Haleem
Jul 7, 2012·Progress in Neurobiology·José Julio RodríguezAlexei Verkhratsky
Sep 17, 2013·Neuropathology and Applied Neurobiology·Elena Redondo-CastroCarme Auladell
Mar 15, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Alessandra ColciagoFabio Celotti
May 11, 2016·Alcoholism, Clinical and Experimental Research·Catherine A MarcinkiewczThomas L Kash
Apr 25, 2018·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Jennifer N K NyarkoDarrell D Mousseau
Sep 22, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Le WangFeng Liu
Aug 28, 2021·International Journal of Molecular Sciences·Grzegorz ŚlifirskiJadwiga Turło
Oct 8, 2020·Cell Metabolism·María Arnoriaga-RodríguezJosé Manuel Fernández-Real

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