PMID: 8590277Jan 1, 1995Paper

Modulation of corneal heme oxygenase expression by oxidative stress agents

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
T K NeilN G Abraham

Abstract

Heme oxygenase, the rate-limiting enzyme in the degradation of heme to bile-pigments and carbon monoxide, is induced in response to increased oxidative stress and is believed to provide a cytoprotective effect. We investigated the role of heme oxygenase in cultured rabbit corneal epithelial cells (RCE), and its potential to alleviate oxidative stress-induced cell damage. Heme oxygenase in RCE was effectively and potently induced by most metals tested, including tin, silver, and gold, and cytokines such as IL-6, and TGF beta. Stannous chloride and heme-induced heme oxygenase mRNA by 40 and 100 fold within 1-3 hours and increased enzyme activity by 9.2- and 10-fold, respectively, over a 24 hour period. IL-6, TGF beta and H2O2 induced heme oxygenase by 2-3 fold. Zinc protoporphyrins were effective inhibitors of heme oxygenase activity in vitro. However, when incubated with cells for 24 h they induced heme oxygenase mRNA but decreased or had no effect on its activity. Administration of heme, SnCl2, and H2O2 resulted in some degree of glutathione perturbation (GSH/GSSG). However, in all cases, depletion of glutathione was exacerbated if heme oxygenase was simultaneously inhibited. Conversely, perturbation of glutathione levels was m...Continue Reading

References

Dec 23, 1977·Science·M D Maines, A Kappas
Jan 1, 1990·Free Radical Research Communications·M GrootveldA Furst
Jan 1, 1990·Free Radical Research Communications·R Stocker
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S M Keyse, R M Tyrrell
Jan 1, 1988·The International Journal of Biochemistry·N G AbrahamS Shibahara
Feb 1, 1994·Immunology Today·H Baumann, J Gauldie
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y LavrovskyN G Abraham
Apr 1, 1993·Journal of Neurochemistry·J F Ewing, M D Maines
May 28, 1993·Biochemical and Biophysical Research Communications·Y Fukuda, S Sassa

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Citations

Jan 7, 2004·Journal of Photochemistry and Photobiology. B, Biology·Mario CiuffiPaola Failli
Apr 25, 1997·Biochemical Pharmacology·M Laniado-SchwartzmanA Kappas
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·S QuanA Kappas
Apr 29, 2008·Investigative Ophthalmology & Visual Science·Kiran PatilMichal Laniado Schwartzman
Dec 27, 2008·The Journal of Investigative Dermatology·Vivienne E ReeveLynette Blyth
Aug 23, 2008·Free Radical Biology & Medicine·Akiva ShohamHyman M Schipper
Jul 8, 2008·Experimental Eye Research·Lars BellnerMichal Laniado-Schwartzman
Feb 10, 2004·Biochemical and Biophysical Research Communications·Shou QuanNader G Abraham
Jun 23, 2012·Current Eye Research·Jun ZhaoDing Sun
Jan 4, 1998·Journal of Cellular Biochemistry·B M DeramaudtN G Abraham
Apr 8, 2006·Physiological Reviews·Stefan W RyterAugustine M K Choi
Mar 8, 2008·Pharmacological Reviews·Nader G Abraham, Attallah Kappas
Oct 12, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Nader G AbrahamMichael S Wolin
Aug 20, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Fengyun XuDeanna L Kroetz
Mar 10, 1999·The American Journal of Physiology·D M SuttnerP A Dennery

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