PMID: 8938661Nov 1, 1996Paper

Modulation of cortical acetylcholine release by serotonin: the role of substance P interneurons

Naunyn-Schmiedeberg's Archives of Pharmacology
T J FeuersteinG B Landwehrmeyer

Abstract

The cholinergic system exerts an important modulatory effect on hippocampal functions. Presynaptic inhibition of hippocampal and neocortical acetylcholine (ACh) release by serotonin (5-HT) has been reported in both rat and human brain. There is some controversy, however, concerning the 5-HT receptor which mediates the inhibitory effects of 5-HT. Using slices of the hippocampal formation of rat prelabelled with [3H]-overflow ([3H]-choline, superfused and depolarized electrically (2 min, 3 Hz, 2 ms, 24 mA) or by K+ (20 mM) we observed that 5-HT inhibits hippocampal and entorhinal [3H]-overflow ([3H]-ACh release) by 5-HT1B receptors located on cholinergic terminals. However, this inhibition requires the functional elimination of substance P/gamma-aminobutyric acid (SP/GABA) interneurons which express 5-HT2A receptors as shown by in situ hybridisation histochemistry. Activation of these somadendritically located 5-HT2a receptors facilitates SP release. SP, in turn, stimulates hippocampal [3H]-ACh release through NK1 receptors present on cholinergic terminals. These findings suggest close links between cholinergic afferents, SP interneurons and 5-HT2 receptors. A loss of cholinergic afferents and 5-HT2 receptors, along with a reduct...Continue Reading

Citations

May 25, 2005·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Sep 13, 2005·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Jarmo HietalaOlof Solin
Jan 16, 2004·Pharmacology, Biochemistry, and Behavior·Anthony C Santucci, Vahram Haroutunian
Feb 28, 2001·European Journal of Pharmacology·P W BurnetP J Harrison
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·Daniel Lin, Loren H Parsons
Sep 3, 2002·Neuroscience Research·Seloua Mounir, André Parent
Apr 26, 2003·Neurobiology of Aging·J VersijptJakob Korf
Jun 1, 1997·Journal of Pharmacological and Toxicological Methods·T J FeuersteinM Schumacher
Mar 11, 2000·The European Journal of Neuroscience·M Kouznetsova, A Nistri
May 28, 2011·Acta Physiologica Hungarica·Ercan OzdemirN Durmus
Apr 11, 2015·Neuroscience and Biobehavioral Reviews·Victoria FasickTracey A Ignatowski
May 1, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Yukihiko ShirayamaRyuzou Kawahara
Apr 6, 2006·The American Psychologist·Roger Walsh, Shauna L Shapiro

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