Modulation of corticosterone does not affect the acquisition or expression of ethanol-induced conditioned place preference in DBA/2J mice

Pharmacology, Biochemistry, and Behavior
J A Chester, C L Cunningham

Abstract

Several recent studies have implicated the stress hormone corticosterone in modulating the rewarding properties of abused drugs, including amphetamine and ethanol. The present experiments examined a role for corticosterone in modulating the rewarding effects of ethanol in the place conditioning paradigm. Male DBA/2J mice were subjected to a Pavlovian conditioning procedure in which a distinctive floor stimulus (CS+) was paired four times with ethanol (2 g/kg). On intervening days, a different floor stimulus was paired with saline (CS-). In the first experiment, the steroid synthesis inhibitor, aminoglutethimide (AMG), administered prior to conditioning trials with ethanol, did not alter the acquisition of place preference. However, during conditioning trials, ethanol-stimulated locomotor activity in the AMG-treated group was significantly higher relative to the vehicle-treated group, suggesting that corticosterone may normally inhibit ethanol-stimulated activity. Plasma corticosterone levels in AMG-treated mice were significantly lower than in vehicle-treated mice, showing that AMG effectively suppressed corticosterone release on CS+ trials. The second experiment examined the effect of AMG on the expression of conditioned ethan...Continue Reading

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Citations

Aug 15, 2002·Pharmacology, Biochemistry, and Behavior·Christopher L CunninghamTara L Fidler
Jun 17, 1999·Pharmacology, Biochemistry, and Behavior·J A Chester, C L Cunningham
Jun 12, 2002·Alcohol·Julia A Chester, Christopher L Cunningham
Aug 11, 2004·Behavioral Neuroscience·Janel M Boyce-Rustay, Christopher L Cunningham
Mar 23, 2007·Genes, Brain, and Behavior·Y A BlednovR F Margolskee
Feb 9, 2010·Pharmacology, Biochemistry, and Behavior·Julia A Chester, Laran E Coon
Dec 25, 2007·European Journal of Pharmacology·Rajkumar J SevakCharles P France
Oct 7, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·G Rodriguez-AlarcónA Salvador
Feb 14, 2015·The Journal of Pharmacology and Experimental Therapeutics·Yuri A BlednovR Adron Harris

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