Modulation of cytochrome P450 gene expression and arachidonic acid metabolism during isoproterenol-induced cardiac hypertrophy in rats

Drug Metabolism and Disposition : the Biological Fate of Chemicals
Beshay N M ZordokyA O El-Kadi

Abstract

Several cytochrome P450 (P450) enzymes have been identified in the heart, and their levels have been reported to be altered during cardiac hypertrophy. Moreover, there is a strong correlation between P450-mediated arachidonic acid metabolites and the pathogenesis of cardiac hypertrophy. Therefore, we investigated the effect of isoproterenol-induced cardiac hypertrophy on the expression of several P450 genes and their associated P450-derived metabolites of arachidonic acid. Cardiac hypertrophy was induced by seven daily i.p. injections of 5 mg/kg isoproterenol. Thereafter, the heart, lung, liver, and kidney were harvested, and the expression of different genes was determined by real-time polymerase chain reaction. Heart microsomal protein from control or isoproterenol treated rats was incubated with 50 microM arachidonic acid, and arachidonic acid metabolites were determined by liquid chromatography-electron spray ionization-mass spectrometry. Our results show that isoproterenol treatment significantly increased the heart/body weight ratio and the hypertrophic markers. In addition, there was a significant induction of CYP1A1, CYP1B1, CYP4A3, and soluble epoxide hydrolase and a significant inhibition of CYP2C11 and CYP2E1 in the ...Continue Reading

References

Mar 31, 2000·Trends in Pharmacological Sciences·W B Campbell
Apr 18, 2000·Lancet·T Thum, J Borlak
Jun 26, 2001·Journal of Biochemical and Molecular Toxicology·K B BleicherD R Umbenhauer
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Aug 9, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Auinash KalsotraHenry W Strobel
Oct 11, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Thomas Thum, Jürgen Borlak
May 21, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Sui WangMi-Sook Kim
Aug 6, 2003·Trends in Molecular Medicine·Oliver Ritter, Ludwig Neyses
Jan 13, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sook Jeong LeeJohn R Dietz
Jul 20, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Dharamainder ChoudharyJohn B Schenkman
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·Deanna L Kroetz, Fengyun Xu
Jan 19, 2006·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·F HirasawaT Sugiyama
Mar 15, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Sandra J BaldwinStephen E Clarke
Jul 11, 2006·Pharmacology & Therapeutics·Reem H Elbekai, Ayman O S El-Kadi
Nov 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Danyan XuNipavan Chiamvimonvat
Jan 16, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Tracy C DelozierJoyce A Goldstein
Apr 14, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Valerie Y NgDeanna L Kroetz
Jul 31, 2007·Journal of Pharmacological and Toxicological Methods·Beshay N M Zordoky, Ayman O S El-Kadi
Feb 22, 2008·Current Drug Metabolism·Beshay N M Zordoky, Ayman O S El-Kadi

❮ Previous
Next ❯

Citations

Feb 3, 2012·Physiological Reviews·John D Imig
Aug 4, 2012·PloS One·Eunhee ChungLeslie A Leinwand
Mar 20, 2013·BioMed Research International·Mohamed A M El Gendy, Ayman O S El-Kadi
Jan 17, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Zaid H MaayahAyman O S El-Kadi
Apr 23, 2013·Drug Metabolism Reviews·Abdulaziz M S AlsaadAyman O S El-Kadi
Jun 10, 2009·Expert Opinion on Drug Metabolism & Toxicology·Rüdiger Kaspera, Rheem A Totah
Jan 7, 2014·Expert Opinion on Drug Metabolism & Toxicology·Nadia AspromonteMassimo Iacoviello
Dec 27, 2012·Vascular Pharmacology·Osama H ElshenawyAyman O S El-Kadi
Oct 5, 2010·Journal of Ethnopharmacology·Abdulqader A AlhaiderAyman O S El-Kadi
Jan 23, 2010·Pharmacology & Therapeutics·Beshay N M Zordoky, Ayman O S El-Kadi
Dec 9, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Beshay N M Zordoky, Ayman O S El-Kadi
Feb 27, 2016·Molecular Pharmaceutics·Ahmed A El-Sherbeni, Ayman O S El-Kadi
Oct 11, 2015·Toxicology and Applied Pharmacology·Samya ElkhataliAyman O S El-Kadi
Nov 28, 2012·British Journal of Pharmacology·Hassan N AlthurwiAyman O S El-Kadi
May 25, 2013·Gene·Todd R Harris, Bruce D Hammock
Jun 12, 2012·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Anwar Anwar-MohamedAyman O S El-Kadi
Feb 16, 2013·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Anwar Anwar-MohamedAyman O S El-Kadi
Jul 15, 2015·Journal of Cardiovascular Pharmacology·Huiying ZhaoChengwen Sun
May 2, 2015·Journal of Physiology and Biochemistry·Nawal M Al-RasheedRaeesa A Mohamad
Oct 3, 2012·Journal of Ethnopharmacology·Mohamed A M El GendyAyman O S El-Kadi
May 15, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Issa E A AmaraAyman O S El-Kadi
Dec 24, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Katja Dralle MjosChris Orvig
Nov 8, 2016·Drug Metabolism Reviews·Ahmed A El-Sherbeni, Ayman O S El-Kadi
Jan 13, 2017·Biology of Sex Differences·Marianne K O GrantBeshay N Zordoky
Apr 25, 2017·Journal of Cardiovascular Pharmacology·Samya ElkhataliAyman O S El-Kadi
Dec 3, 2017·Cardiovascular Toxicology·Zaid H MaayahAyman O S El-Kadi
Apr 11, 2019·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Elizabeth A HausnerXi Yang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Drug Metabolism and Disposition : the Biological Fate of Chemicals
Abdulaziz M S AlsaadA O El-Kadi
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
T Thum, J Borlak
Journal of Pharmacological and Toxicological Methods
Beshay N M Zordoky, A O El-Kadi
Drug Metabolism and Disposition : the Biological Fate of Chemicals
Dharamainder ChoudharyJohn B Schenkman
© 2022 Meta ULC. All rights reserved