Modulation of cytokine levels in ameliorative effects of pulsed magnetic field on an experimental model of Chronic Constriction Injury

International Journal of Radiation Biology
Tufan MertIsmail Gunay

Abstract

Clinical chronic neuropathic pain is often resistant to currently used pharmacotherapeutic applications. A number studies have shown that pulsed magnetic field (PMF) application may ameliorate the pain associated with damages, surgeries or diseases. However, possible potential mechanisms of PMF treatments have not been well documented. This study aimed to assess the therapeutic effects of PMF treatment on a Chronic Constriction Injury model (CCI) which mimics clinical chronic neuropathic pain symptoms. Effects of PMF treatments or sham PMF (SPMF) were investigated by measuring the latencies, thresholds and cytokine levels (interleukin [IL]-1 beta, IL-6 and IL-10) of sciatic nerve in CCI or sham surgery rats. PMF was treated on CCI rats before (a day after surgery, PMF-AD) and after (a week after surgery, PMF-AW) the development of pain signs. Rats exhibited hyperalgesia and allodynia within one week following surgery, and lasted through the experiment. PMF treatments, but not SPMF, significantly enhanced the latency and threshold. Both anti-hyperalgesic and anti-allodynic actions of PMF-AD were greater than those of PMF-AW treatment. Similarly, PMF-AD had more pronounced effects on the level of pro- and anti-inflammatory cytoki...Continue Reading

References

Aug 1, 1995·British Journal of Anaesthesia·A Dray
Feb 11, 1999·Journal of Neuroscience Research·F M LongoB F Sisken
Aug 26, 2003·Legal Medicine·Stephen John Hopkins
Aug 26, 2003·Advanced Drug Delivery Reviews·Lili X Wang, Zaijie Jim Wang
Sep 29, 2004·Pharmacology·Tufan MertYusuf Kenan Daglioglu
Jan 4, 2006·Brain Research Reviews·Gila Moalem, David J Tracey
Mar 22, 2007·Neuroscience and Biobehavioral Reviews·Cristina Del SeppiaMartin Kavaliers
Apr 12, 2007·International Anesthesiology Clinics·Jun-Ming Zhang, Jianxiong An
Jun 15, 2007·European Journal of Pharmacology·Tufan Mert
Aug 25, 2007·Anesthesia and Analgesia·Michael A ThackerStephen B McMahon
Apr 18, 2009·Aesthetic Surgery Journal·Berish StrauchArthur A Pilla
Feb 16, 2010·Nature Reviews. Immunology·Margarida Saraiva, Anne O'Garra
Jul 21, 2010·Neuroscience Letters·John A RobertsonAlex W Thomas
Mar 3, 2011·Bioelectromagnetics·Ismail Gunay, Tufan Mert
Sep 2, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sylvain NadeauSteve Lacroix
Dec 18, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Paola SacerdoteAlberto E Panerai

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