PMID: 7536622Apr 1, 1995Paper

Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand

Immunity
A WindhagenD A Hafler

Abstract

We demonstrate that cognate peptide ligands altered at T cell receptor (TCR) contact residues and bound to class II major histocompatability complex can change the cytokine pattern of mature T cell clones. Myelin basic protein peptide 85-99-reactive Th0 T cell clones were stimulated with altered peptide ligands, which acted both as TCR antagonist and induced new mRNA synthesis and protein secretion of TGF-beta 1, while no longer inducing mRNA synthesis or protein secretion of IL-2, IL-4, IL-10, and IFN gamma. The modified peptides failed to induce a detectable calcium flux, p56lck activation, or thymidine incorporation, yet triggered nearly equal amounts of IL-4 secretion in the presence of ionomycin. Antigen-induced modulation of T cell cytokine secretion may be important in regulating the immune response.

References

Jul 26, 1976·Biochemical and Biophysical Research Communications·L S SmithR A Smith
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C E RuddS F Schlossman
Jan 1, 1989·Cold Spring Harbor Symposia on Quantitative Biology·C A JanewayD B Murphy
Jan 1, 1981·Annual Review of Biochemistry·F Wold
Oct 1, 1994·The Journal of Experimental Medicine·J Sloan-LancasterP M Allen
Jan 1, 1994·Annual Review of Immunology·S Romagnani
Jan 14, 1994·Cell·K A HogquistF R Carbone
Jan 28, 1993·Nature·M J Berridge
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A B KulkarniS Karlsson
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J RuppertA Sette

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Citations

Apr 29, 1998·Biotherapy·J M van Noort
Jan 1, 1997·Clinical Reviews in Allergy & Immunology·T MusuJ P Dandeu
Sep 2, 1998·Immunologic Research·C M Seroogy, C G Fathman
Jul 1, 1996·Immunology Letters·S MatsushitaY Nishimura
Jun 14, 2005·Cellular Immunology·Stanislav Vukmanović, Fabio R Santori
Mar 24, 2004·Molecular Immunology·Jacqueline Shukaliak QuandtRoland Martin
Mar 24, 2004·Molecular Immunology·Jean-Marie FourneauJean-François Bach
Dec 10, 1998·Journal of Neuroimmunology·A Pohl-KoppeD A Hafler
Mar 1, 1997·Immunology Today·O WilliamsD Kioussis
Jan 29, 1999·Research in Immunology·V K Kuchroo, H L Weiner
Apr 1, 1996·Current Opinion in Immunology·A M Kruisbeek, D Amsen
May 3, 2003·Trends in Molecular Medicine·Stanislav VukmanovićFabio R Santori
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·R GreenwoodJ A Frelinger
Sep 26, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hiroto KitaM Eric Gershwin
Sep 17, 1996·Proceedings of the National Academy of Sciences of the United States of America·L RacioppiS Zappacosta
Feb 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·J D RabinowitzH M McConnell
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·C N LeveltS Tonegawa
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·H L Weiner
Apr 1, 1996·The Journal of Experimental Medicine·K VidalP M Allen
Jun 1, 1996·The Journal of Experimental Medicine·P Brossart, M J Bevan
Jul 1, 1996·The Journal of Experimental Medicine·C Reis e SousaR N Germain
Jan 31, 1998·The Journal of Experimental Medicine·K R Ryan, B D Evavold
Mar 2, 1999·The Journal of Experimental Medicine·B Seddon, D Mason
Apr 6, 1999·The Journal of Experimental Medicine·S PingelR M Locksley
Apr 20, 1999·The Journal of Experimental Medicine·P J RuizL Steinman
Jul 9, 2003·The Journal of Experimental Medicine·Dong-Gyun LimDavid A Hafler

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