Modulation of cytokine/chemokine production in human macrophages by bisphenol A: A comparison to analogues and interactions with genistein

Journal of Immunotoxicology
Yingjia ChenTai L Guo

Abstract

The immunotoxicant bisphenol A (BPA) may produce toxic effects on organs and systems, in part, by altering the secretion of cytokines and chemokines. However, systematic studies of the effects of BPA, let alone of its analogs and in cases when there are interactions with other chemicals, on innate immunity and cytokine modulation are limited. The objectives of this study were to investigate the immunomodulatory effects of: (1) BPA and its analogs, BPS and BPAF; and (2) the interaction between BPA and genistein (GEN), a partial estrogen agonist or antagonist. BPA, BPS, and BPAF were incubated with PMA-differentiated-U937 cells (a widely used cell line for primary human macrophages) at concentrations of 0, 0.1, 1, 10, 100 µM for up to 96 h. BPA (0, 0.1, 1, 10 µM) and GEN (0, 1, 10 µM) were also applied at various combinations. Cell viability and 30 cytokines/chemokines were measured. The results showed that the cell viability-inhibiting effect of these three bisphenols was BPAF > BPA > BPS. At 0.1 µM, BPA and BPAF generally increased the secretion of cytokines/chemokines, while BPS had minimal effects. All three bisphenols generally suppressed the secretion of cytokines/chemokines at 1 µM, while increased their secretion at 10 µM...Continue Reading

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Citations

May 31, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Hyelim KimWoo Kyung Moon
Sep 11, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jiongjie JingAlmudena Veiga-Lopez
Dec 29, 2018·Autoimmunity·Gali AljadeffYehuda Shoenfeld
Nov 13, 2019·Journal of Biochemical and Molecular Toxicology·Suwei ZhangXianheng Wu
Feb 15, 2021·Ecotoxicology and Environmental Safety·Yingchun ZhangZhixian Gao
Nov 17, 2020·Dose-response : a Publication of International Hormesis Society·Somya Z MansourHebatallah E Mohamed
May 11, 2021·Environmental Pollution·Tatiana Fernandes Araujo AlmeidaTarcília Aparecida Silva
May 19, 2021·The Science of the Total Environment·Shenbagamoorthy SundarrajRajaretinam Rajesh Kannan
Aug 28, 2019·Environmental Science & Technology·Chao ZhaoZongwei Cai

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