Mar 10, 2020

Modulation of DNA and RNA by PNA

Bioorganic & Medicinal Chemistry Letters
Penthip Muangkaew, Tirayut Vilaivan

Abstract

Peptide nucleic acid (PNA), a synthetic DNA mimic that is devoid of the (deoxy)ribose-phosphate backbone yet still perfectly retains the ability to recognize natural nucleic acids in a sequence-specific fashion, can be employed as a tool to modulate gene expressions via several different mechanisms. The unique strength of PNA compared to other oligonucleotide analogs is its ability to bind to nucleic acid targets with secondary structures such as double-stranded and quadruplex DNA as well as RNA. This digest aims to introduce general readers to the advancement in the area of modulation of DNA/RNA functions by PNA, its current status and future research opportunities, with emphasis on recent progress in new targeting modes of structured DNA/RNA by PNA and PNA-mediated gene editing.

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Mentioned in this Paper

Analogs & derivatives
RNA, Double-Stranded
DNA
DNA Binding
Extraordinary Opportunities for Investment
Area
2-deoxyribose 1-phosphate, (alpha-D-erythro)-isomer
Nucleic Acids
RNA
Structure

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