Modulation of DNA and RNA by PNA

Bioorganic & Medicinal Chemistry Letters
Penthip Muangkaew, Tirayut Vilaivan

Abstract

Peptide nucleic acid (PNA), a synthetic DNA mimic that is devoid of the (deoxy)ribose-phosphate backbone yet still perfectly retains the ability to recognize natural nucleic acids in a sequence-specific fashion, can be employed as a tool to modulate gene expressions via several different mechanisms. The unique strength of PNA compared to other oligonucleotide analogs is its ability to bind to nucleic acid targets with secondary structures such as double-stranded and quadruplex DNA as well as RNA. This digest aims to introduce general readers to the advancement in the area of modulation of DNA/RNA functions by PNA, its current status and future research opportunities, with emphasis on recent progress in new targeting modes of structured DNA/RNA by PNA and PNA-mediated gene editing.

Citations

Jul 23, 2020·Organic & Biomolecular Chemistry·Chayan Charoenpakdee, Tirayut Vilaivan
Jun 17, 2020·Chemistry : a European Journal·Klara AradiMaria Duca
Aug 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Oleg V MarkovMarina A Zenkova
Sep 6, 2020·Chembiochem : a European Journal of Chemical Biology·Penthip Muangkaew, Tirayut Vilaivan
Oct 31, 2020·Chembiochem : a European Journal of Chemical Biology·Zhe SuiXingguo Liang
Jun 16, 2021·Biopolymers·J Dinithi R PereraPeter M Glazer
Aug 10, 2021·Beilstein Journal of Organic Chemistry·Nikita BrodyaginEriks Rozners
Sep 4, 2021·Analytical and Bioanalytical Chemistry·Nuttapon JirakittiwutThanit Praneenararat

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