Modulation of drug transport properties by multicomponent diffusion in surfactant aqueous solutions

Langmuir : the ACS Journal of Surfaces and Colloids
Huixiang Zhang, Onofrio Annunziata

Abstract

Diffusion coefficients of drug compounds are crucial parameters used for modeling transport processes. Interestingly, diffusion of a solute can be generated not only by its own concentration gradient but also by concentration gradients of other solutes. This phenomenon is known as multicomponent diffusion. A multicomponent diffusion study on drug-surfactant-water ternary mixtures is reported here. Specifically, high-precision Rayleigh interferometry was used to determine multicomponent diffusion coefficients for the hydrocortisone-tyloxapol-water system at 25 degrees C. For comparison, diffusion measurements by dynamic light scattering were also performed. In addition, drug solubility was measured as a function of tyloxapol concentration, and drug-surfactant thermodynamic interactions using the two-phase partitioning model were characterized. The diffusion results are in agreement with a proposed coupled multicomponent diffusion model for ternary mixtures relevant to nonionic drug and surfactant molecules. Theoretical examination of diffusion-based drug transport in the presence of concentration gradients of micelles shows that drug fluxes and drug concentration profiles are significantly affected by coupled multicomponent diff...Continue Reading

References

Jan 30, 1999·Journal of Colloid and Interface Science·O Regev, R Zana
Jul 9, 1999·Journal of Colloid and Interface Science·O AnnunziataV Vitagliano
Jun 9, 2001·Journal of Colloid and Interface Science·Gerardino D'ErricoVincenzo Vitagliano
Jan 1, 1961·Biophysical Journal·M A LAUFFER
Feb 19, 2005·Critical Reviews in Therapeutic Drug Carrier Systems·Deenu G Kanjickal, Stephanie T Lopina
Dec 14, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Onofrio AnnunziataJohn G Albright
Sep 26, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Songmiao LiangLina Zhang
Mar 6, 2008·The Journal of Physical Chemistry. B·Huixiang Zhang, Onofrio Annunziata

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Citations

Oct 19, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Dan KeWeiguo Shen
Sep 24, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Michele S McAfeeOnofrio Annunziata
Dec 12, 2012·International Journal of Pharmaceutics·Ana C F RibeiroMiguel A Esteso
Aug 20, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Wyatt J MusnickiRonald J Phillips
Nov 12, 2020·Soft Matter·Nathan P AlexanderStephanie R Dungan
Feb 18, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Eliandreina Cruz Barrios, Onofrio Annunziata
Aug 27, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Huixiang Zhang, Onofrio Annunziata
Sep 26, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Nathan P AlexanderStephanie R Dungan

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