Modulation of dynamic modes by interplay between positive and negative feedback loops in gene regulatory networks

Physical Review. E
Liu-Suo WangWei Wang

Abstract

A positive and a negative feedback loop can induce bistability and oscillation, respectively, in biological networks. Nevertheless, they are frequently interlinked to perform more elaborate functions in many gene regulatory networks. Coupled positive and negative feedback loops may exhibit either oscillation or bistability depending on the intensity of the stimulus in some particular networks. It is less understood how the transition between the two dynamic modes is modulated by the positive and negative feedback loops. We developed an abstract model of such systems, largely based on the core p53 pathway, to explore the mechanism for the transformation of dynamic behaviors. Our results show that enhancing the positive feedback may promote or suppress oscillations depending on the strength of both feedback loops. We found that the system oscillates with low amplitudes in response to a moderate stimulus and switches to the on state upon a strong stimulus. When the positive feedback is activated much later than the negative one in response to a strong stimulus, the system exhibits long-term oscillations before switching to the on state. We explain this intriguing phenomenon using quasistatic approximation. Moreover, early switchin...Continue Reading

References

Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·K L OhlsenJ A Hoch
Jan 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Didier GonzeAlbert Goldbeter
Sep 10, 2002·Trends in Biochemical Sciences·Lindsey D Mayo, David B Donner
Mar 22, 2003·Current Opinion in Cell Biology·John J TysonBela Novak
Jul 24, 2003·The Journal of Biological Chemistry·Gisela D'AngeloChristian Frelin
Apr 2, 2004·Current Microbiology·Sasha H Shafikhani, Terrance Leighton
Oct 13, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Xiao-Peng ZhangWei Wang
Apr 11, 2008·Neuron·Hiromi ShimojoRyoichiro Kageyama
Oct 18, 2008·Science·Onn Brandman, Tobias Meyer
Oct 31, 2008·Nature Reviews. Molecular Cell Biology·Béla Novák, John J Tyson
Feb 7, 2009·PloS One·Keng Boon WeeBaltazar D Aguda
Apr 28, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Paul SmolenJohn H Byrne
May 27, 2009·PLoS Computational Biology·Smita AgrawalDavid V Schaffer
Aug 8, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Xiao-Jun TianWei Wang
Aug 18, 2009·Genes & Development·Taeko KobayashiRyoichiro Kageyama
Jun 16, 2010·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Taeko Kobayashi, Ryoichiro Kageyama
May 18, 2011·Proceedings of the National Academy of Sciences of the United States of America·Xiao-Peng ZhangWei Wang
Feb 4, 2012·PLoS Biology·Joe H LevineMichael B Elowitz
Jun 16, 2012·Science·Jeremy E PurvisGalit Lahav
Jan 8, 2014·The Journal of Biological Chemistry·James BagnallViolaine Sée
Apr 9, 2014·BMC Systems Biology·Berta VerdJohannes Jaeger

❮ Previous
Next ❯

Citations

Oct 1, 2020·Journal of the Royal Society, Interface·Atchuta Srinivas DudduMohit Kumar Jolly

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.