Modulation of E-cadherin expression promotes migration ability of esophageal cancer cells

Scientific Reports
Shujun LiHelin Zhang

Abstract

Losing the E-cadherin plays an important role in the metastasis of cancer. The regulation of the expression of E-cadherin is unclear. Circadian rhythm alteration is associated with the pathogenesis of a number of cancers. This study aims to investigate the role of one of the circadian proteins, period-2 (Per2) in repressing the expression of E-cadherin in esophageal cancer (esophageal cancer). We observed that the levels of circadian protein Per2 were significantly increased and E-cadherin was significantly decreased in the tissue of human esophageal cancer with metastasis as compared with non-metastatic esophageal cancer. Overexpression of Per2 in the esophageal cancer cells markedly repressed the expression of E-cadherin. The pHDAC1 was detected in human esophageal cancer with metastasis, which was much less in the esophageal cancer tissue without metastasis. Overexpression of Per2 increased the levels of pHDAC1 as well as the E-cadherin repressors at the E-cadherin promoter locus. Overexpression of Per2 markedly increased the migratory capacity of esophageal cancer cells, which was abolished by the inhibition of HDAC1. We conclude that Per-2 plays an important role in the esophageal cancer cell metastasis, which may be a nov...Continue Reading

References

May 18, 2007·Nature Reviews. Cancer·Héctor PeinadoAmparo Cano
Jun 26, 2007·Cells, Tissues, Organs·K-F BeckerH Höfler
May 15, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jean-Christophe Leloup, Albert Goldbeter
Sep 9, 2010·Cell Communication and Signaling : CCS·Matteo Parri, Paola Chiarugi
Apr 21, 2011·Expert Review of Anticancer Therapy·George SgourakisHauke Lang
Jun 18, 2011·Science·Hao A DuongCharles J Weitz
Dec 20, 2011·Cell Communication & Adhesion·Andrea Buda, Massimo Pignatelli
Apr 5, 2012·International Journal of Cancer. Journal International Du Cancer·Genevieve M MonseesEva S Schernhammer
Oct 12, 2012·PloS One·Kelly CoffeyCraig N Robson
Apr 23, 2013·Handbook of Experimental Pharmacology·Biliana MarchevaJoseph Bass
Jun 8, 2013·Cancer Letters·E Aaron Runkle, David Mu
Aug 1, 2013·Progress in Molecular Biology and Translational Science·Jennifer A Evans, Alec J Davidson
Sep 26, 2013·Journal of Dental Research·S PapagerakisP Papagerakis
Dec 11, 2013·International Journal of Biological Macromolecules·Jiasheng ZhengCaixia Hu
Feb 8, 2014·Gastroenterology Clinics of North America·Joel H Rubenstein, Joan W Chen
Apr 26, 2014·World Journal of Gastroenterology : WJG·Gianluigi MazzoccoliAda Piepoli
May 17, 2014·World Journal of Gastrointestinal Oncology·Kyle J NapierSubhasis Misra
Jul 6, 2014·Disease Models & Mechanisms·Sean R MooreChristian I Hong
Jul 22, 2014·International Journal of Cancer. Journal International Du Cancer·Sander A HuismanRon W F de Bruin
Oct 17, 2014·World Journal of Gastrointestinal Oncology·Rachit D ShahJames P Neifeld
Mar 31, 2015·Investigative Ophthalmology & Visual Science·Lauren A Dalvin, Michael P Fautsch

❮ Previous
Next ❯

Citations

May 27, 2017·World Journal of Surgical Oncology·Kang LiuGang Feng
Jun 16, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Ting-Juan ZhangJun Qian
Dec 7, 2018·The European Journal of Neuroscience·Lydia HannouValérie Mongrain
Dec 7, 2018·Frontiers in Genetics·Yaroslav R EfremovSergey S Bogachev
Jan 21, 2020·Journal of Cellular and Molecular Medicine·Zeru FengXikun Zhou

❮ Previous
Next ❯

Methods Mentioned

BETA
ChIP
PCR
protein assay
immunoprecipitation assay

Software Mentioned

ImageJ

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.