Modulation of emotions associated with images of human pain using anodal transcranial direct current stimulation (tDCS)

Neuropsychologia
Paulo S BoggioFelipe Fregni

Abstract

Viewing images of other humans in pain elicits a variety of responses including distress, anxiety, and a sensation that is similar to pain. We aimed to evaluate whether transcranial direct current stimulation (tDCS) could be effective in modulating the emotional aspects of pain as to further explore mechanisms of tDCS in pain relief. Twenty-three healthy subjects rated images with respect to unpleasantness and discomfort/pain (baseline), and then received stimulation with tDCS under four different conditions of stimulation: anodal tDCS of the left primary motor cortex (M1), dorsolateral prefrontal cortex (DLPFC), occipital cortex (V1); and sham tDCS. The order of conditions was randomized and counterbalanced across subjects. During each stimulation session (after 3 min of stimulation), subjects were shown a new set of aversive images and were again asked to rate the images with respect to unpleasantness and discomfort/pain. The results showed that ratings of unpleasantness and discomfort/pain were significantly decreased during DLPFC tDCS only, as compared to baseline and sham tDCS. The other conditions of stimulation (M1 and V1 tDCS) did not result in any significant changes. These results support the notion that DLPFC is a cr...Continue Reading

References

Mar 6, 1999·Pain·R D TreedeA K Jones
Jun 28, 2000·Neuropsychologia·S F TaylorR A Koeppe
Oct 12, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·I LiberzonS Minoshima
Jun 30, 2001·Journal of Neurophysiology·R K HofbauerM C Bushnell
Aug 17, 2001·Journal of Cognitive Neuroscience·J R SimpsonM E Raichle
Jan 25, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·H C TenenbaumK D Davis
May 17, 2002·Current Opinion in Neurobiology·Pierre Rainville
Apr 11, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Alberto Priori
Apr 12, 2003·Brain : a Journal of Neurology·J LorenzK L Casey
May 27, 2003·Journal of Psychiatric Research·Uwe HerwigCarlos Schönfeldt-Lecuona
Feb 26, 2004·Current Pain and Headache Reports·Gordon Blackburn-Munro
Jul 7, 2005·Experimental Brain Research·Felipe FregniAlvaro Pascual-Leone
Jan 24, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Prateek C GandigaLeonardo G Cohen
Jun 10, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Pedro Cavaleiro MirandaMark Hallett
Jul 18, 2006·Journal of the Neurological Sciences·Paulo S BoggioFelipe Fregni
Nov 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fabio GodinhoLuis Garcia-Larrea
Dec 22, 2006·Pain·Michael I BennettTroels Staehelin Jensen
Jan 24, 2007·Lancet Neurology·Felipe FregniAlvaro Pascual-Leone
Mar 14, 2007·Revue neurologique·M DuquetteP Rainville
Apr 21, 2007·Annual Review of Biomedical Engineering·Timothy WagnerAlvaro Pascual-Leone
May 16, 2007·The Journal of Nervous and Mental Disease·David H AveryPeter Roy-Byrne
May 22, 2007·NeuroImage·Xavier Moisset, Didier Bouhassira
Jun 8, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shirley FecteauFelipe Fregni
Jun 15, 2007·The International Journal of Neuropsychopharmacology·Paulo S BoggioFelipe Fregni
Jun 16, 2007·Biological Psychiatry·Karl-Jürgen BärHeinrich Sauer
Jun 23, 2007·Cerebral Cortex·Alberto PrioriG Sartori
Oct 2, 2007·Journal of Pain and Symptom Management·Gisele SilvaFelipe Fregni
Dec 15, 2007·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Jeffery J BorckardtMark S George
Dec 22, 2007·Somatosensory & Motor Research·Wolfgang FreundBernd Schmitz
Feb 29, 2008·Journal of Cognitive Neuroscience·Agnes FlöelCaterina Breitenstein

❮ Previous
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Citations

Oct 13, 2011·Experimental Brain Research·Liron JacobsonMichal Lavidor
May 24, 2011·Neuropsychological Rehabilitation·Giuseppe Vallar, Nadia Bolognini
Apr 13, 2012·Neuromodulation : Journal of the International Neuromodulation Society·Sven Vanneste, Dirk De Ridder
Dec 20, 2012·Journal of Cognitive Neuroscience·Silvia ConventoNadia Bolognini
Jul 19, 2012·PloS One·Kathleen JoosDirk De Ridder
Feb 22, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·B VaseghiS Jaberzadeh
Oct 18, 2013·Social Cognitive and Affective Neuroscience·Zaira CattaneoCamilo J Cela-Conde
Sep 10, 2014·Experimental Brain Research·Kevin T JonesMarian E Berryhill
Jan 28, 2016·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Timothy Y MarianoBenjamin D Greenberg
Jan 17, 2013·World Neurosurgery·Dirk De RidderSven Vanneste
Apr 10, 2012·The Journal of Pain : Official Journal of the American Pain Society·Ela B PlowAndre Machado
Apr 21, 2012·The Journal of Pain : Official Journal of the American Pain Society·Jay S ReidlerFelipe Fregni
Jul 7, 2010·Neuroscience Research·David Hecht
Apr 8, 2009·Experimental Neurology·Michael A NitscheAlvaro Pascual-Leone
Feb 10, 2011·Human Brain Mapping·Nadia BologniniCarlo Miniussi
Jul 8, 2015·European Journal of Applied Physiology·Luca AngiusAlexis R Mauger
Mar 18, 2015·Restorative Neurology and Neuroscience·Tommaso BocciFerdinando Sartucci
Mar 26, 2015·Neuroscience Letters·Gabriel G RêgoPaulo S Boggio
Nov 8, 2012·TheScientificWorldJournal·Jae-Jin SongDirk De Ridder
Jun 12, 2013·Neuroscience Research·Mikhail VotinovTatsuya Mima
Jul 4, 2015·Attention, Perception & Psychophysics·Thiago L CostaDora F Ventura
Apr 17, 2012·Brain Stimulation·Sébastien HétuPhilip L Jackson
Mar 26, 2015·Frontiers in Human Neuroscience·Philip L JacksonDanny Beaudoin
Feb 15, 2015·Neuroscience Bulletin·Min-Fang Kuo, Michael A Nitsche
Jun 2, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Andre Russowsky BrunoniAlberto Priori

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