PMID: 3752266Sep 1, 1986Paper

Modulation of endothelium-dependent responses by chronic alterations of blood flow

The American Journal of Physiology
V M MillerP M Vanhoutte

Abstract

To determine whether the blood flow and O2 tension to which a blood vessel is chronically exposed could modulate endothelium-dependent responses, these parameters were altered in the dog either by causing partial occlusion of the femoral artery or by creating a fistula between the femoral artery and vein. Blood flow was reduced by 75% in the clamped artery; mean arterial pressure was unchanged. In the vessels proximal to the fistula, blood flow was elevated and O2 tensions were similar in the vein and artery. After 6 wk the femoral arteries and veins were excised, and their endothelium-dependent responses were studied in vitro. The endothelium-dependent relaxations to acetylcholine, adenosine diphosphate, and alpha 2-adrenergic stimulation were augmented in fistula-operated compared with sham-operated arteries. The responses to these agents in the clamp-operated vessels were not different from those of the sham-operated ones. Relaxation to arachidonic acid in the arteries showed an inverse relationship to blood flow. In the veins proximal to the fistula, the endothelium-dependent relaxations to acetylcholine were augmented and an endothelium-dependent relaxation to alpha 2-adrenergic stimulation was present; only a contractile ...Continue Reading

Citations

Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·H T YangR L Terjung
Oct 4, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Chen-Fuh LamZvonimir S Katusic
Sep 18, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Changdong YanDong Sun
Jan 31, 2002·World Journal of Gastroenterology : WJG·Ying-Qiu HuangJian-Zhong Mo
Jun 2, 2006·American Journal of Physiology. Cell Physiology·Charles D Searles

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