Modulation of experimental allergic encephalomyelitis by a host-versus-graft reaction: a clinicopathological study.

Journal of Neuroimmunology
M StaykovaI Goranov

Abstract

The effect of timing of a local host-versus-graft reaction on the induction of acute experimental allergic encephalomyelitis (EAE) was studied in guinea pigs. 20 x 10(7) gamma-irradiated allogeneic cells injected 4 days after encephalitogenic challenge resulted in the development of EAE with an earlier onset, an increased delayed-type hypersensitivity (DTH) response and an increase in lymphoid cell infiltration in the spinal cord. Challenge with allogeneic cells on days -4 and -7, however, produced a delay in onset and a protracted course of disease, with 30-40% of the animals recovering. Evidence of disease was confirmed histologically.

References

Jan 1, 1977·International Archives of Allergy and Applied Immunology·K Nagasawa, R Mori
Oct 1, 1978·Journal of the Neurological Sciences·A B Keith
Jan 1, 1988·International Archives of Allergy and Applied Immunology·M Mostarica-StojkovićM L Lukić
Jun 1, 1987·Transplantation·I AokiK Okuda
Jan 1, 1985·Critical Reviews in Clinical Laboratory Sciences·H Bril, R Benner
Feb 1, 1985·Cellular Immunology·D O WillenborgG Danta
Jan 1, 1981·Immunological Reviews·P Y PatersonC C Whitacre
Jan 1, 1980·International Archives of Allergy and Applied Immunology·Y KurodaT Aoki
Jul 1, 1986·Immunology Today·G KrämerG Wick

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