Abstract
Formosanin-C, a diosgenin saponin, was isolated from a perennial herb, Paris formosana Hayata (Liliaceae) which has been used as a folk remedy for snake bite and as an anti-inflammatory or anti-neoplastic agent. Its effect on the development of S-antigen-induced experimental autoimmune uveitis (EAU) in guinea pigs was studied. Guinea pigs treated with formosanin-C (1.5 mg/kg/2 days and 0.5 mg/kg/2 days) were compared with untreated guinea pigs in regard to the development of EAU, lymphocytic proliferative responses, and anti-S-antigen serum antibodies. The higher dosage of formosanin-C (1.5 mg/kg) obviously delayed the onset of EAU. Treatment of this drug, 1.5 mg/kg and 0.5 mg/kg doses, significantly inhibited the specific lymphocytic response of lymph node and spleen cells to S-antigen. On the contrary, treatment in 1.5 mg/kg dose significantly increased the response of lymph node and spleen cells to the polyclonal T cell mitogen, phytohemagglutinin (PHA). Treatment with formosanin-C in both the 1.5 mg/kg and 0.5 mg/kg doses had a minimal effect on the lymphocytic response of lymph node to concanavalin-A (ConA), while a noticeable suppressive effect on the response of spleen cells to ConA was observed in the 1.5 mg/kg dose. Th...Continue Reading
References
Jul 1, 1979·Journal of Pharmaceutical Sciences·P R RavikumarC J Sih
Oct 1, 1988·Clinical Immunology and Immunopathology·S A SkolikR A Hess
Feb 1, 1988·Journal of Ethnopharmacology·A SugayaE Sugaya
May 1, 1987·Immunobiology·S R Chavali, J B Campbell
Jul 1, 1987·Current Eye Research·G DoekesA Kijlstra
May 1, 1986·Canadian Journal of Microbiology·I MaharajJ B Campbell
Aug 1, 1985·Ophthalmology·C C ChanD Benezra
Feb 16, 1972·Nature: New Biology·M C LiK P Hsu
Jan 28, 1972·Nature·D M Henricks, D R Lamond
Jan 1, 1984·International Archives of Allergy and Applied Immunology·M T ScottL Chedid
Sep 1, 1982·Pediatric Research·J R Alvarez, R Torres-Pinedo
Jul 1, 1982·Archives of Ophthalmology·R B NussenblattW Wacker
Aug 1, 1980·Drugs·G Renoux
Jan 1, 1982·International Archives of Allergy and Applied Immunology·R Bomford
Feb 1, 1980·American Journal of Ophthalmology·R B NussenblattW B Wacker
Citations
Aug 6, 2011·Journal of Ethnopharmacology·Shuli ManChangxiao Liu
Sep 23, 2014·Chemistry & Biodiversity·Jin-Chao WeiPei-Gen Xiao
Aug 28, 2021·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Limin YinMing Li