Modulation of experimental autoimmune encephalomyelitis by administration of cells expressing antigenic peptide covalently linked to MHC class II

Journal of Neuroimmunology
Andreas WeishauptThomas Herrmann

Abstract

The MHC class II molecule RT1Bl covalently linked with gpMBP-71-90 was expressed in P80 cells (mouse mastocytoma P815 expressing rat-CD80) and i.v. injection ameleriorated active and adoptive transfer (AT) experimental autoimmune encephalomyelitis (EAE) in Lewis rats. Spinal cord of animals with AT-EAE showed significant increase of apoptotic T-cells at maximum of disease after injection of P80-RT1Bl-MBP-71-90 but not of P80RT1Bl or P80 cells. The data demonstrate a possible therapeutic effect on EAE by provision of T-cell receptor (TCR) and costimulatory signals by genetically engineered antigen presenting cells (APC) and suggest induction of T-cell apoptosis as important mechanism of action.

References

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Jul 1, 1997·International Immunology·K MaedaK Okumura
Feb 1, 2000·Molecular Medicine Today·R GoldK V Toyka

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Citations

Dec 1, 2009·Journal of Neural Transmission·Michael K BoettgerClaudia Sommer
May 15, 2013·Journal of Neuroimmunology·Monika CamaraThomas Kerkau
Aug 12, 2006·Multiple Sclerosis : Clinical and Laboratory Research·J PlumbM N Woodroofe

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