PMID: 2485681Sep 1, 1989Paper

Modulation of experimental autoimmune uveoretinitis by adoptive transfer of cells from rats immunized with anti-S-antigen monoclonal antibody

Regional Immunology
Y de KozakJ P Faure

Abstract

Preimmunization of rnu/+ rats with the mouse monoclonal antibody S2D2 against retinal S-antigen (S-Ag) leads to an anti-idiotypic (anti-Id) response and to protection against experimental autoimmune uveoretinitis (EAU) provoked by a subsequent challenge with S-Ag in complete Freund's adjuvant (CFA). Suppression of EAU can be passively transferred using lymph node and/or spleen cells from donors with active anti-Id immunity to naive rnu/+ recipients, prior to immunization with bovine S-Ag in CFA. In contrast, passive administration of IgG from S2D2-immunized rats did not produce suppression. High levels of anti-Id S2D2 antibodies were found: (1) in rats presenting an inhibited EAU after sensitization with S2D2 or after passive transfer of anti-S2D2 cells prior to the S-Ag immunization; and (2) in rats with a severe EAU after transfer of anti-S2D2 IgG associated with anti-S2D2 cells prior to the S-Ag challenge. No effect on the anti-S-Ag antibody level could be detected. These experiments suggest that EAU, a mostly T cell-dependent disease, can be down regulated by anti-Id lymphoid cells.

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.