Modulation of feeding-related peptide/protein signals by the blood-brain barrier

Journal of Neurochemistry
Weihong PanA J Kastin

Abstract

The peptide urocortin is a member of the corticotropin-releasing factor (CRF) family and a potent satiety signal to the brain. Urocortin in blood does not reach the brain significantly by itself, but its permeation across the blood-brain barrier (BBB) can be enhanced by leptin. How leptin facilitates the influx of urocortin has not been elucidated. In this study, we tested the hypothesis that leptin activates receptor-mediated endocytosis of urocortin. We measured the kinetics of permeation of radioactively labeled urocortin across the mouse BBB and determined the specific effects of leptin and receptor antibodies. The results show that the influx transfer constant of urocortin was enhanced in the presence of leptin and mediated by CRF-2beta, the specific receptor for urocortin. To determine the specificity of this modulation, the effect of leptin was compared with that of TNFalpha. Both TNFalpha and leptin independently facilitated receptor-mediated transport of urocortin across the BBB. Even though TNFalpha and leptin have similar effects on urocortin transport, leptin did not significantly affect the influx of TNFalpha across the BBB. The results indicate that permeation of ingestive peptides and cytokines across the BBB can...Continue Reading

Citations

Oct 24, 2007·Journal of Molecular Neuroscience : MN·Weihong PanAbba J Kastin
Dec 24, 2005·Nature Reviews. Neuroscience·N Joan AbbottElisabeth Hansson
May 10, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Weihong PanAbba J Kastin
Mar 19, 2009·Brain : a Journal of Neurology·Hung HsuchouWeihong Pan
Dec 18, 2008·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Chuanhui YuWeihong Pan
Apr 6, 2006·The AAPS Journal·Ken A Witt, Thomas P Davis
Feb 23, 2010·Endocrinology·William A Banks
Oct 11, 2011·Journal of Neurosurgery·Hock-Kean LiewCheng-Yoong Pang
May 27, 2008·Brain, Behavior, and Immunity·Jessica L Lynch, William A Banks
Oct 24, 2007·Peptides·Weihong PanAbba J Kastin
May 22, 2009·Journal of Neurochemistry·Yan ZhangWeihong Pan
Feb 27, 2007·Journal of Cellular Physiology·Hong TuAbba J Kastin
Feb 11, 2009·Cell Biochemistry and Function·Yusuf Ziya ZiylanRasim Mogulkoc
Dec 15, 2007·Progress in Neurobiology·Weihong Pan, Abba J Kastin
Mar 13, 2016·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Weihong Pan, Abba J Kastin
Sep 29, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Hung HsuchouWeihong Pan
Nov 3, 2009·Biochimica Et Biophysica Acta·William A Banks

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