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Modulation of FGF-2 binding to chondrocytes from the developing growth plate by perlecan

Matrix Biology : Journal of the International Society for Matrix Biology

Feb 17, 2006

Prasanthi GovindrajJohn R Hassell

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Abstract

FGF-2 is a regulator of chondrocyte proliferation in the developing growth plate and has been shown to bind to perlecan, a heparan sulfate proteoglycan. We evaluated the effect of perlecan isolated from the growth plate on the binding of FGF-2 to its low and high affinity receptors on r...read more

Mentioned in this Paper

Bone Structure of Rib
Iodine Isotopes
Chondrocyte Proliferation
Cell Culture Techniques
ACAN gene
Bos taurus
Chondrocyte
Aggrecans
Plasma Protein Binding Capacity
Cell Proliferation
9
Paper Details
References
  • References18
  • Citations14
12
  • References18
  • Citations14
12

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Modulation of FGF-2 binding to chondrocytes from the developing growth plate by perlecan

Matrix Biology : Journal of the International Society for Matrix Biology

Feb 17, 2006

Prasanthi GovindrajJohn R Hassell

PMID: 16481152

DOI: 10.1016/j.matbio.2006.01.003

Abstract

FGF-2 is a regulator of chondrocyte proliferation in the developing growth plate and has been shown to bind to perlecan, a heparan sulfate proteoglycan. We evaluated the effect of perlecan isolated from the growth plate on the binding of FGF-2 to its low and high affinity receptors on r...read more

Mentioned in this Paper

Bone Structure of Rib
Iodine Isotopes
Chondrocyte Proliferation
Cell Culture Techniques
ACAN gene
Bos taurus
Chondrocyte
Aggrecans
Plasma Protein Binding Capacity
Cell Proliferation
9

Feeds With Similar Papers

Extracellular Matrix Turnover

The extracellular matrix (ECM) ensures tissue integrity and play a role in cell growth, migration, and differentiation. ECM turnover, therefore, is essential for tissue maintenance. Here is the latest research on mechanisms that regulate ECM turnover.

Extracellular Matrix Adhesion

Multiprotein adhesion structures allow the interaction of a cell with the extracellular matrix comprised of extracellular molecules that ensure tissue integrity and play a role in cell growth, migration, and differentiation. Here is the latest research.

Related Papers

The Journal of Biological Chemistry

Isolation and identification of the major heparan sulfate proteoglycans in the developing bovine rib growth plate

The Journal of Biological ChemistryMarch 23, 2002
Prasanthi GovindrajJohn R Hassell
Matrix Biology : Journal of the International Society for Matrix Biology

Heparan and chondroitin sulfate on growth plate perlecan mediate binding and delivery of FGF-2 to FGF receptors

Matrix Biology : Journal of the International Society for Matrix BiologyDecember 16, 2006
Simone M-L SmithJohn R Hassell
Paper Details
References
  • References18
  • Citations14
12
  • References18
  • Citations14
12

Download from

Publisher
PubMed
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