Modulation of functional activity and connectivity by acupuncture in patients with Alzheimer disease as measured by resting-state fMRI

PloS One
Weimin ZhengZhiqun Wang

Abstract

Acupuncture has been used in the therapy of Alzheimer disease (AD); however, its neural mechanisms are still unclear. The aim of this study is to examine the effect of acupuncture on the functional connectivity in AD by using resting-state functional magnetic resonance imaging (rs-fMRI). Twenty-eight subjects (14 AD and 14 normal controls) participated in this study. The rs-fMRI data were acquired before and after acupuncture stimulation at the acupoints of Tai chong (Liv3) and Hegu (LI4). During the baseline resting state, by using the amplitude of low-frequency fluctuations (ALFF), we found a significantly decreased or increased ALFF in the AD patients relative to the controls. These regions were located in the right superior frontal gyrus (SFG), left postcentral gyrus, subgenual cingulate cortex (SCC), right middle cingulate cortex (MCC), right inferior frontal gyrus (IFG), right hippocampus and the right inferior temporal gyrus (ITG). Then, we selected these brain regions as seeds to investigate whether regional activity and functional connectivity could be modulated by acupuncture in the AD patients. When compared to the pre-acupuncture stage, several of the above regions showed an increased or decreased ALFF after acupunc...Continue Reading

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Citations

Nov 25, 2020·Neural Regeneration Research·Chao-Chao YuLi-Hong Kong
Dec 8, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Shi-Yi QiZhi-Xin Wang
Jan 8, 2021·Frontiers in Neuroscience·Chao-Chao YuLi-Hong Kong
Apr 17, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaoling LiFeng Wang
May 23, 2021·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Gregory P Casey
May 18, 2021·Frontiers in Neural Circuits·Xiao-Kuo HeTsung-Hsun Hsieh

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Methods Mentioned

BETA
imaging technique

Software Mentioned

rs
ALFF
fMRI

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